Landgraf Dominic, McCarthy Michael J, Welsh David K
Research Service, Veterans Affairs San Diego Healthcare System.
Behav Neurosci. 2014 Jun;128(3):344-59. doi: 10.1037/a0036029. Epub 2014 Mar 24.
An association between circadian clock function and mood regulation is well established and has been proposed as a factor in the development of mood disorders. Patients with depression or mania suffer disturbed sleep-wake cycles and altered rhythms in daily activities. Environmentally disrupted circadian rhythms increase the risk of mood disorders in the general population. However, proof that a disturbance of circadian rhythms is causally involved in the development of psychiatric disorders remains elusive. Using clock gene mutants, manipulations of sleep-wake and light-dark cycles, and brain lesions affecting clock function, animal models have been developed to investigate whether circadian rhythm disruptions alter mood. In this review, selected animal models are examined to address the issue of causality between circadian rhythms and affective behavior.
昼夜节律功能与情绪调节之间的关联已得到充分证实，并被认为是情绪障碍发生发展的一个因素。患有抑郁症或躁狂症的患者睡眠-觉醒周期紊乱，日常活动节奏改变。环境扰乱的昼夜节律会增加普通人群患情绪障碍的风险。然而，昼夜节律紊乱在精神疾病发生发展中起因果作用的证据仍然难以捉摸。利用生物钟基因敲除小鼠、对睡眠-觉醒和明暗周期的操控以及影响生物钟功能的脑损伤，已经建立了动物模型来研究昼夜节律紊乱是否会改变情绪。在这篇综述中，我们研究了一些选定的动物模型，以探讨昼夜节律与情感行为之间的因果关系问题。
