State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.
ACS Appl Mater Interfaces. 2014 Apr 23;6(8):5860-8. doi: 10.1021/am500715f. Epub 2014 Apr 4.
Aqueous Au nanoparticles (NPs) are employed as the building blocks to construct chainlike self-assembly architectures, which greatly enhance the photothermal performance at 808 nm. Biocompatible polypyrrole (PPy) is further adopted as the package material to coat Au NP chains, producing stable photothermal agents. As a result of contributions from chainlike Au, the PPy shell, as well as the Au-PPy composite structures, the capability of photothermal transduction at 808 nm is greatly enhanced, represented by the high photothermal transduction efficiency up to 70%. Primary animal experiment proves that the current composite photothermal agents are efficient in inhibiting tumor growth under an 808 nm irradiation, showing the potentials for in vivo photothermal therapy.
水相金纳米粒子 (Au NPs) 被用作构建链状自组装结构的构建块，这大大提高了在 808nm 处的光热性能。进一步采用生物相容性的聚吡咯 (PPy) 作为包裹材料来包覆 Au NP 链，得到稳定的光热试剂。由于链状 Au、PPy 壳以及 Au-PPy 复合结构的贡献，在 808nm 处的光热转换能力得到了极大的提高，表现为高达 70%的高光热转换效率。初步的动物实验证明，在 808nm 照射下，当前的复合光热试剂能有效抑制肿瘤生长，显示出在体内光热治疗方面的潜力。
