College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , 2999 North Renmin Road, Shanghai 201620, China.
ACS Appl Mater Interfaces. 2015 Feb 25;7(7):4354-67. doi: 10.1021/am508837v. Epub 2015 Feb 17.
Construction of multifunctional nanocomposites as theranostic platforms has received considerable biomedical attention. In this study, a triple-functional theranostic agent based on the cointegration of gold nanorods (Au NRs) and superparamagnetic iron oxide (Fe3O4) into polypyrrole was developed. Such a theranostic agent (referred to as Au/PPY@Fe3O4) not only exhibits strong magnetic property and high near-infrared (NIR) optical absorbance but also produces high contrast for magnetic resonance (MR) and X-ray computed tomography (CT) imaging. Importantly, under the irradiation of the NIR 808 nm laser at the power density of 2 W/cm(2) for 10 min, the temperature of the solution containing Au/PPY@Fe3O4 (1.4 mg/mL) increased by about 35 °C. Cell viability assay showed that these nanocomposites had low cytotoxicity. Furthermore, an in vitro photothermal treatment test demonstrates that the cancer cells can be efficiently killed by the photothermal effects of the Au/PPY@Fe3O4 nanocomposites. In summary, this study demonstrates that the highly versatile multifunctional Au/PPY@Fe3O4 nanocomposites have great potential in simultaneous multimodal imaging-guided cancer theranostic applications.
构建多功能纳米复合材料作为治疗平台已经引起了相当多的生物医学关注。在这项研究中，基于金纳米棒（Au NRs）和超顺磁性氧化铁（Fe3O4）共嵌入聚吡咯，开发了一种三重功能治疗剂。这种治疗剂（称为 Au/PPY@Fe3O4）不仅具有强磁性和高近红外（NIR）光吸收性，而且还能产生磁共振（MR）和 X 射线计算机断层扫描（CT）成像的高对比度。重要的是，在功率密度为 2 W/cm2 的 NIR 808 nm 激光照射 10 分钟后，含有 Au/PPY@Fe3O4（1.4 mg/mL）的溶液温度升高了约 35°C。细胞活力测定表明这些纳米复合材料具有低细胞毒性。此外，体外光热治疗试验表明，癌细胞可以通过 Au/PPY@Fe3O4 纳米复合材料的光热效应被有效杀死。总之，本研究表明，多功能的 Au/PPY@Fe3O4 纳米复合材料具有在同时进行多模态成像引导癌症治疗中的巨大潜力。
