Hamada Kaoru, Haruyama Sanehito, Yamaguchi Takashi, Yamamoto Kayo, Hiromasa Kana, Yoshioka Manabu, Nishio Daisuke, Nakamura Motonobu
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Exp Dermatol. 2014 May;23(5):316-7. doi: 10.1111/exd.12380.
Human body odour and earwax type are genetically dependent on a single-nucleotide polymorphism (SNP) located in the ABCC11 gene. So far, it still remains to be clear how SNP in the ABCC11 gene is associated with human malodour. In a recent issue of Experimental Dermatology, Baumann et al. propose one of the underlying molecular pathways. Although one of the amino acid conjugated of the odorants, Cys-Gly-3-methyl-3-sulfanylhexanol (3M3SH), was not taken up by the transporter ABCC11, glutathione conjugate of 3MSH (SG-3MSH) was transported by ABCC11. Moreover, SG-3MSH was processed to 3M3SH by γ-glutamyl-transferase 1 (GGT1), which was abundantly expressed in apocrine sweat glands. These findings may pave a way for the pharmacogenetics of human body odour and the development of innovative deodorant products.
人体气味和耳垢类型在基因上取决于位于ABCC11基因中的单核苷酸多态性（SNP）。到目前为止，ABCC11基因中的SNP如何与人类恶臭相关仍不清楚。在最近一期的《实验皮肤病学》中，鲍曼等人提出了一种潜在的分子途径。尽管气味剂的一种氨基酸共轭物，即半胱氨酸 - 甘氨酸 - 3 - 甲基 - 3 - 硫烷基己醇（3M3SH）不被转运蛋白ABCC11摄取，但3 - 甲基硫代己醇（3MSH）的谷胱甘肽共轭物（SG - 3MSH）被ABCC11转运。此外，SG - 3MSH被γ - 谷氨酰转移酶1（GGT1）加工成3M3SH，GGT1在顶泌汗腺中大量表达。这些发现可能为人体气味的药物遗传学和创新除臭产品的开发铺平道路。
