Naughton Felix, Jamison James, Boase Sue, Sloan Melanie, Gilbert Hazel, Prevost A Toby, Mason Dan, Smith Susan, Brimicombe James, Evans Robert, Sutton Stephen
Behavioural Science Group, Institute of Public Health, University of Cambridge, Cambridge, UK.
Addiction. 2014 Jul;109(7):1184-93. doi: 10.1111/add.12556. Epub 2014 Apr 24.
To estimate the short-term effectiveness, feasibility and acceptability of a smoking cessation intervention (the iQuit system) that consists of tailored printed and Short Message Service (SMS) text message self-help delivered as an adjunct to cessation support in primary care to inform the design of a definitive trial.
A stratified two parallel-group randomized controlled trial comparing usual care (control) with usual care plus the iQuit system (intervention), delivered by primary care nurses/healthcare assistants who were blinded to the allocation sequence.
Thirty-two general practice (GP) surgeries in England, UK.
A total of 602 smokers initiating smoking cessation support from their local GP surgery were randomized (control n = 303, intervention n = 299).
Primary outcome was self-reported 2-week point prevalence abstinence at 8 weeks follow-up. Secondary smoking outcomes and feasibility and acceptability measures were collected at 4 weeks after quit date, 8 weeks and 6 months follow-up.
There were no significant between-group differences in the primary outcome [control 40.3%, iQuit 45.2%; odds ratio (OR) = 1.22, 95% confidence interval (CI) = 0.88-1.69] or in secondary short-term smoking outcomes. Six-month prolonged abstinence was significantly higher in the iQuit arm (control 8.9%, iQuit 15.1%; OR = 1.81, 95% CI = 1.09-3.01). iQuit support took on average 7.7 minutes (standard deviation = 4.0) to deliver and 18.9% (95% CI = 14.8-23.7%) of intervention participants discontinued the text message support during the programme.
Tailored printed and text message self-help delivered alongside routine smoking cessation support in primary care does not significantly increase short-term abstinence, but may increase long-term abstinence and demonstrated feasibility and acceptability compared with routine cessation support alone.
评估一种戒烟干预措施（iQuit系统）的短期有效性、可行性和可接受性。该系统包括量身定制的印刷材料和短信自助服务，作为初级保健戒烟支持的辅助手段，为一项确定性试验的设计提供信息。
一项分层两组平行随机对照试验，将常规护理（对照组）与常规护理加iQuit系统（干预组）进行比较，由对分配顺序不知情的初级保健护士/医疗保健助理实施。
英国英格兰的32家全科医疗诊所。
共有602名开始从当地全科医疗诊所寻求戒烟支持的吸烟者被随机分组（对照组n = 303，干预组n = 299）。
主要结局是在随访8周时自我报告的2周时点戒烟率。在戒烟日期后4周、8周和6个月随访时收集次要吸烟结局以及可行性和可接受性指标。
主要结局在组间无显著差异[对照组40.3%，iQuit组45.2%；优势比（OR）= 1.22，95%置信区间（CI）= 0.88 - 1.69]，次要短期吸烟结局也无显著差异。iQuit组6个月的持续戒烟率显著更高（对照组8.9%，iQuit组15.1%；OR = 1.81，95% CI = 1.09 - 3.01）。提供iQuit支持平均耗时7.7分钟（标准差 = 4.0），18.9%（95% CI = 14.8 - 23.7%）的干预组参与者在项目期间停止了短信支持。
在初级保健中，与常规戒烟支持一起提供量身定制的印刷材料和短信自助服务，不会显著提高短期戒烟率，但与单独的常规戒烟支持相比，可能会提高长期戒烟率，并显示出可行性和可接受性。
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