液相色谱法在生物医学和环境分析中对手性药物的对映体拆分：综述

Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview.

作者信息

Ribeiro Ana R, Maia Alexandra S, Cass Quezia B, Tiritan Maria E

机构信息

CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal; CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal; Centro de Química Medicinal da Universidade do Porto (CEQUIMED-UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

出版信息

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 1;968:8-21. doi: 10.1016/j.jchromb.2014.02.049. Epub 2014 Mar 12.

DOI:10.1016/j.jchromb.2014.02.049

PMID:24661858

Abstract

This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed.

摘要

本综述旨在介绍使用手性固定相（CSP）对生物和环境基质中的手性药物进行对映体分离所涉及的问题。因此，它阐述了液相色谱（LC）中的一些对映体选择性方法，并比较了生物医学和环境领域中对映体分离的重要性。为此，对最常用的CSP、对映体选择性色谱方法、它们的优缺点进行了快速回顾和比较。还讨论了LC中手性分析方法的最新进展和局限性。