Amoedo Nivea Dias, Rodrigues Mariana Figueiredo, Rumjanek Franklin David
Instituto de Bioquimica Médica Leopoldo De Meis, Universidade Federal do Rio de Janeiro, Brazil.
Instituto de Bioquimica Médica Leopoldo De Meis, Universidade Federal do Rio de Janeiro, Brazil.
Int J Biochem Cell Biol. 2014 Jun;51:53-7. doi: 10.1016/j.biocel.2014.03.009. Epub 2014 Mar 21.
Since the nineteenth century the importance of mitochondria in cellular physiology has been growing steadily. Not only the organelle harbors the main systems for ATP generation, but also buffers the redox potential in the cytosol and is one of the protagonists of the intrinsic pathway for apoptosis. In tumor cells, mitochondria went from being dysfunctional compartments to playing a supportive or perhaps even a triggering part in metastasis. This "Organelle In Focus" article discusses the classical metabolic events that occur in mitochondria and why these pathways could be essential for the onset of the malignant phenotype. Finally, we propose that the oxidative metabolism of tumor cells in conjunction with the inactivation of anoikis may have been coopted through a non-adaptive evolutionary process.
自19世纪以来，线粒体在细胞生理学中的重要性一直在稳步增长。该细胞器不仅拥有产生ATP的主要系统，还能缓冲细胞质中的氧化还原电位，并且是细胞凋亡内在途径的主要参与者之一。在肿瘤细胞中，线粒体已从功能失调的区室转变为在转移过程中发挥支持甚至触发作用的角色。这篇“聚焦细胞器”文章讨论了线粒体中发生的经典代谢事件，以及为什么这些途径可能对恶性表型的发生至关重要。最后，我们提出肿瘤细胞的氧化代谢与失巢凋亡的失活可能是通过一个非适应性进化过程而被利用的。
