GABAB 脑炎患者的治疗临床表现和结果。
Clinical manifestations and outcomes of the treatment of patients with GABAB encephalitis.
机构信息
Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
出版信息
J Neuroimmunol. 2014 May 15;270(1-2):45-50. doi: 10.1016/j.jneuroim.2014.02.011. Epub 2014 Feb 28.
Encephalitis associated with anti-γ-aminobutyric acid-B (GABAB) receptor antibodies has been identified recently. However, only a few cases have been reported to date and its clinical manifestations and prognosis have not been investigated systematically. We identified five cases of GABAB encephalitis in Korea. Here we present the clinical features, treatment responses, and brain positron emission tomography findings of the cases. The patients had a clinical triad of memory changes, seizure, and association with small-cell lung cancer. Early diagnosis and comprehensive immune modulation may provide a good outcome.
最近已经确定了与抗γ-氨基丁酸-B（GABAB）受体抗体相关的脑炎。然而，迄今为止仅报道了少数病例，并且尚未对其临床表现和预后进行系统研究。我们在韩国鉴定了五例 GABAB 脑炎病例。在此，我们介绍了这些病例的临床特征、治疗反应和脑正电子发射断层扫描结果。患者具有记忆改变、癫痫发作和小细胞肺癌的三联征。早期诊断和全面免疫调节可能提供良好的预后。
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