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妊娠期抗γ-氨基丁酸B（GABA B）抗体受体相关自身免疫性脑炎：一种罕见疾病。

Anti-Gamma Aminobutyric Acid B (GABA B) Antibody Receptor-Associated Autoimmune Encephalitis in Pregnancy: A Rare Condition.

作者信息

Mazumdar Md Aziz, Bansal Sonali, Shukla Isha

机构信息

Medicine, Park Hospital, Gurgaon, IND.

Critical Care Medicine, Park Hospital, Gurgaon, IND.

出版信息

Cureus. 2024 Nov 11;16(11):e73494. doi: 10.7759/cureus.73494. eCollection 2024 Nov.

DOI:10.7759/cureus.73494
PMID:39669839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11635330/
Abstract

We report a primigravida 31-year-old female patient hospitalized at 32 gestational weeks with status epilepticus. In due course of illness, she developed refractory status epilepticus managed with induced coma with propofol and emergency early lower section caesarean surgery (LSCS). A battery of initial laboratory and radiological tests did not lead to a definite diagnosis. On further workup, she was diagnosed with anti-gamma aminobutyric acid B (GABA B) receptor autoimmune encephalitis that responded to immunotherapy and pulse steroids.

摘要

我们报告了一名31岁的初产妇，在孕32周时因癫痫持续状态入院。在病程中，她发展为难治性癫痫持续状态，采用丙泊酚诱导昏迷和急诊早期低位剖宫产手术（LSCS）进行治疗。一系列初步实验室和影像学检查未得出明确诊断。进一步检查后，她被诊断为抗γ-氨基丁酸B（GABA B）受体自身免疫性脑炎，对免疫治疗和冲击性类固醇治疗有反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c47d/11635330/1c93e0945e33/cureus-0016-00000073494-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c47d/11635330/fd00493be519/cureus-0016-00000073494-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c47d/11635330/1c93e0945e33/cureus-0016-00000073494-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c47d/11635330/fd00493be519/cureus-0016-00000073494-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c47d/11635330/1c93e0945e33/cureus-0016-00000073494-i02.jpg

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本文引用的文献

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Encephalitis With Antibodies Against the GABA Receptor: High Mortality and Risk Factors.抗γ-氨基丁酸受体脑炎：高死亡率及危险因素
Front Neurol. 2019 Sep 26;10:1030. doi: 10.3389/fneur.2019.01030. eCollection 2019.
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Clinical characteristics and long-term follow-up of seven cases of anti-GABABR encephalitis in patients of Han Chinese descent.抗 GABABR 脑炎汉族患者 7 例的临床特征和长期随访
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Treatment strategies for autoimmune encephalitis.
自身免疫性脑炎的治疗策略。
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The gamma-aminobutyric acid-B receptor (GABAB) encephalitis: clinical manifestations and response to immunotherapy.γ-氨基丁酸B受体（GABAB）脑炎：临床表现及免疫治疗反应
Int J Neurosci. 2018 Jul;128(7):627-633. doi: 10.1080/00207454.2017.1408618. Epub 2017 Dec 6.
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Status epilepticus in pregnancy: Etiology, management, and clinical outcomes.妊娠相关性癫痫持续状态：病因、管理和临床结局。
Epilepsy Behav. 2017 Nov;76:114-119. doi: 10.1016/j.yebeh.2017.07.002. Epub 2017 Sep 9.
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Clinical, imaging, and follow-up observations of patients with anti-GABA receptor encephalitis.抗γ-氨基丁酸受体脑炎患者的临床、影像学及随访观察
Int J Neurosci. 2017 May;127(5):379-385. doi: 10.1080/00207454.2016.1176922. Epub 2016 May 1.
7
Limbic Encephalitis Associated with Anti-γ-aminobutyric Acid B Receptor Antibodies: A Case Series from China.与抗γ-氨基丁酸B受体抗体相关的边缘叶性脑炎：来自中国的病例系列
Chin Med J (Engl). 2015 Nov 20;128(22):3023-8. doi: 10.4103/0366-6999.168989.
8
Clinical manifestations and outcomes of the treatment of patients with GABAB encephalitis.GABAB 脑炎患者的治疗临床表现和结果。
J Neuroimmunol. 2014 May 15;270(1-2):45-50. doi: 10.1016/j.jneuroim.2014.02.011. Epub 2014 Feb 28.
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Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis.抗 NMDA 受体脑炎：精神病学中重要的鉴别诊断。
Br J Psychiatry. 2011 Dec;199(6):508-9. doi: 10.1192/bjp.bp.111.092197. Epub 2011 Oct 7.
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Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.伴发癫痫的边缘性脑炎中 GABA(B)受体抗体：病例系列及抗原特征
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