Lipinski Michael J, Frias Juan C
*MedStar Cardiovascular Research Network, MedStar Heart Institute, Medstar Washington Hospital Center, Washington, DC; and †Departamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia, Spain.
J Cardiovasc Pharmacol. 2014 Apr;63(4):314-5. doi: 10.1097/FJC.0000000000000070.
The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.
