Leenutaphong V
Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Am Acad Dermatol. 1993 Aug;29(2 Pt 2):337-40. doi: 10.1016/0190-9622(93)70190-5.
An 18-year-old woman developed urticaria approximately 10 minutes after exposure to sunlight. The action spectrum was in the UVA range. Simultaneous irradiation of the skin with UVA and visible light wavelengths shorter than 460 nm induced wheals approximately 10 minutes after the end of the exposure, no matter how long the exposure time. Urticaria induced by UVA radiation was completely inhibited by immediate reirradiation of test sites with visible light wavelengths shorter than 460 nm. Visible light irradiation before exposure to eliciting wavelengths revealed no inhibitory effect, nor was an inhibitory effect found by pre- or postirradiation of test sites with visible light wavelengths longer than 530 nm. These findings suggest that the inactivation of a photoproduct or some subsequent step involved in the pathogenesis of the urticarial reaction was inhibited by visible light wavelengths shorter than 460 nm but not by visible light wavelengths longer than 530 nm.
一名18岁女性在暴露于阳光后约10分钟出现荨麻疹。作用光谱在UVA范围内。无论暴露时间多长，在皮肤同时接受UVA和波长小于460nm的可见光照射后，在照射结束约10分钟后会诱发风团。通过立即用波长小于460nm的可见光重新照射测试部位，可完全抑制由UVA辐射诱发的荨麻疹。在暴露于引发波长之前进行可见光照射未显示出抑制作用，用波长大于530nm的可见光对测试部位进行照射前或照射后也未发现抑制作用。这些发现表明，波长小于460nm的可见光可抑制光产物的失活或荨麻疹反应发病机制中涉及的某些后续步骤，但波长大于530nm的可见光则不能。
