Hinks L J, Ogilvy-Stuart A, Hambidge K M, Walker V
University Department of Chemical Pathology, Southampton General Hospital, UK.
Br J Obstet Gynaecol. 1989 Jan;96(1):61-6. doi: 10.1111/j.1471-0528.1989.tb01577.x.
Zinc and selenium status was assessed in 30 non-pregnant women, 69 women during normal pregnancy, six with a fetus with a neural tube defect (NTD) and 16 who had a raised plasma alpha-fetoprotein (AFP) but no detectable fetal abnormality. Plasma zinc and selenium concentrations were significantly reduced in the second trimester of normal pregnancy compared with non-pregnant levels. A significant decrease in concentrations of zinc in plasma and selenium in plasma and leucocytes was observed in women in the third trimester compared with women in the second trimester. Women with a fetal NTD and women with an unexplained elevation of plasma AFP had significantly lower leucocyte concentrations of zinc and of selenium. Mean values for plasma zinc, plasma and erythrocyte selenium, and for the activity of glutathione peroxidase in whole blood did not differ from those for normal pregnancy.
对30名未怀孕女性、69名正常孕期女性、6名怀有神经管缺陷（NTD）胎儿的女性以及16名血浆甲胎蛋白（AFP）升高但未检测到胎儿异常的女性的锌和硒状况进行了评估。与未怀孕时的水平相比，正常孕期中期血浆锌和硒浓度显著降低。与孕中期女性相比，孕晚期女性血浆锌浓度、血浆和白细胞中硒浓度显著下降。怀有神经管缺陷胎儿的女性以及血浆AFP原因不明升高的女性白细胞中的锌和硒浓度显著较低。血浆锌、血浆和红细胞硒的平均值以及全血中谷胱甘肽过氧化物酶的活性与正常孕期的值没有差异。
