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尼日利亚东北部迈杜古里大学教学医院新生儿破伤风回顾

A review of neonatal tetanus in University of Maiduguri Teaching Hospital, North-eastern Nigeria.

作者信息

Alhaji M A, Bello M A, Elechi H A, Akuhwa R T, Bukar F L, Ibrahim H A

机构信息

Department of Paediatrics, College of Medical Sciences, University of Maiduguri, PMB 1069, Maiduguri, Borno State, Nigeria.

Department of Paediatrics, University of Maiduguri Teaching Hospital, PMB 1114, Maiduguri, Borno State, Nigeria.

出版信息

Niger Med J. 2013 Nov;54(6):398-401. doi: 10.4103/0300-1652.126294.

Abstract

BACKGROUND

Neonatal tetanus is a vaccine preventable disease and is a leading cause of neonatal mortality in developing countries. The effectiveness of immunization and hygienic umbilical cord care practices in the prevention of the disease has been established.

OBJECTIVE

The objective of this study was to audit the scourge of neonatal tetanus in a tertiary health facility in a resource-limited setting.

MATERIALS AND METHODS

The study was a retrospective study. Case notes of neonates admitted with clinical diagnosis of tetanus into the Special Care Baby Unit (SCBU) between January 2009 and December 2010 were retrieved and evaluated to identify socio-demographic and clinical characteristics, mode of acquisition and severity of the disease, presence of co-morbidities, duration of hospital stay and outcome.

RESULTS

Most of the mothers had no tetanus immunization (66.7%) and the main social class of the children was class V (45.1%) and IV (41.2%), respectively. Only 29.4% of the mothers attended ante-natal care (ANC) while majority of the patients were delivered at home (94.1%). Half of the neonates presented with the severe form of the disease (51.0%). Sepsis is a prominent co-morbidity (59.2%). Morality was high with case fatality of 66.7%.

CONCLUSION

This high prevalence of neonatal tetanus with high mortality is not only disappointing but unacceptable in the 21(st) century. Therefore, all efforts must be re-focused on current preventive strategies while pursuing new areas such as slow-release mono-dose tetanus vaccine and school health programme as well as advocacy on political will for the sustainability of immunization programmes of women of child-bearing age.

摘要

背景

新生儿破伤风是一种可通过疫苗预防的疾病,是发展中国家新生儿死亡的主要原因。免疫接种和脐带卫生护理措施在预防该疾病方面的有效性已得到证实。

目的

本研究的目的是在资源有限的环境下,对一家三级医疗机构中新生儿破伤风的祸害进行审计。

材料与方法

本研究为回顾性研究。检索并评估了2009年1月至2010年12月期间因临床诊断为破伤风而入住特殊护理婴儿病房(SCBU)的新生儿病历,以确定社会人口统计学和临床特征、疾病的获得方式和严重程度、合并症的存在、住院时间和结局。

结果

大多数母亲未接种破伤风疫苗(66.7%),儿童的主要社会阶层分别为V级(45.1%)和IV级(41.2%)。只有29.4%的母亲接受了产前护理(ANC),而大多数患者在家中分娩(94.1%)。一半的新生儿表现为疾病的严重形式(51.0%)。败血症是一种突出的合并症(59.2%)。死亡率很高,病死率为66.7%。

结论

新生儿破伤风的高患病率和高死亡率不仅令人失望,在21世纪也是不可接受的。因此,在追求缓释单剂量破伤风疫苗和学校健康计划等新领域以及倡导育龄妇女免疫计划可持续性的政治意愿的同时,所有努力都必须重新聚焦于当前的预防策略。

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