Hibberd Catherine, Cossigny Davina A F, Quan Gerald M Y
Spinal Biology Research Laboratory, University of Melbourne, Department of Surgery, Austin Health, Heidelberg Victoria 3084, Australia. ; Department of Spinal Surgery, Austin Health, Heidelberg Victoria 3084, Australia.
Spinal Biology Research Laboratory, University of Melbourne, Department of Surgery, Austin Health, Heidelberg Victoria 3084, Australia.
Cancer Growth Metastasis. 2013 Aug 1;6:23-34. doi: 10.4137/CGM.S11284. eCollection 2013.
The bony skeleton is one of the most common sites of metastatic spread of cancer and is a significant source of morbidity in cancer patients, causing pain and pathologic fracture, impaired ambulatory ability, and poorer quality of life. Animal cancer models of skeletal metastases are essential for better understanding of the molecular pathways behind metastatic spread and local growth and invasion of bone, to enable analysis of host-tumor cell interactions, identify barriers to the metastatic process, and to provide platforms to develop and test novel therapies prior to clinical application in human patients. Thus, the ideal model should be clinically relevant, reproducible and representative of the human condition. This review summarizes the current in vivo animal models used in the study of cancer metastases of the skeleton.
骨骼是癌症转移最常见的部位之一，也是癌症患者发病的重要原因，会导致疼痛、病理性骨折、行走能力受损以及生活质量下降。骨骼转移的动物癌症模型对于更好地理解转移扩散以及骨骼局部生长和侵袭背后的分子途径至关重要，有助于分析宿主与肿瘤细胞的相互作用，识别转移过程中的障碍，并提供在人类患者临床应用之前开发和测试新疗法的平台。因此，理想的模型应与临床相关、可重复且能代表人类情况。本综述总结了目前用于研究骨骼癌症转移的体内动物模型。
