[环磷酰胺的免疫调节活性]
[Immunotropic activity of cyclophosphane].
作者信息
Leont'eva T I, Gladkova N E, Uteshev B S
出版信息
Farmakol Toksikol. 1988 Nov-Dec;51(6):60-5.
The sensitivity of ram erythrocyte-specific B-cells to cyclophosphane was studied. An antigen and two polyclonal activators, lipopolysaccharide and dextran sulfate, were used as the clone activators. The immunodepressant effect of cyclophosphane was found to depend on the degree of the immunocompetent clone activation. The maximal elimination of the clone under the influence of cyclophosphane occurred after its activation by the antigen and lipopolysaccharide. The drug exerted the minimal effect on the "resting" clone. The degree of suppression of the clone activated by dextran sulfate took the intermediate position.
研究了绵羊红细胞特异性B细胞对环磷酰胺的敏感性。使用一种抗原以及两种多克隆激活剂，即脂多糖和硫酸葡聚糖作为克隆激活剂。发现环磷酰胺的免疫抑制作用取决于免疫活性克隆的激活程度。在抗原和脂多糖激活克隆后，环磷酰胺对克隆的最大消除作用出现。该药物对“静止”克隆的作用最小。由硫酸葡聚糖激活的克隆的抑制程度处于中间位置。
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