Holmgren M, Möller G
Department of Immunobiology, Karolinska Institute, Stockholm, Sweden.
Scand J Immunol. 1980;11(1):85-91. doi: 10.1111/j.1365-3083.1980.tb00212.x.
The primary immune response to untreated sheep erythrocytes (SRBC) in vitro was suppressed by the addition of antibody-coated SRBC. A mixture of SRBC and antibody-coated SRBC also suppressed the induction of anti-SRBC plaque-forming cells by the polyclonal B cell activators lipopolysaccharide, purified protein derivative of tuberculin, and native dextran. Injection of a mixture of SRBC and antibody-coated SRBC into mice led to an increased response to SRBC. It seems plausible from the in vitro findings that the Fc part of antibodies complexed to an antigen can exert a negative signal on antigen-specific B cells that cannot be overcome by positive signals delivered by polyclonal B cell activators.
添加抗体包被的绵羊红细胞（SRBC）可抑制体外对未处理的SRBC的初次免疫反应。SRBC与抗体包被的SRBC的混合物还可抑制多克隆B细胞激活剂脂多糖、结核菌素纯蛋白衍生物和天然葡聚糖诱导的抗SRBC斑块形成细胞。将SRBC与抗体包被的SRBC的混合物注射到小鼠体内会导致对SRBC的反应增强。从体外研究结果来看，与抗原结合的抗体的Fc部分可能会对抗抗原特异性B细胞产生负信号，而多克隆B细胞激活剂传递的正信号无法克服这种负信号，这似乎是合理的。
