B细胞有丝分裂原对体内针对绵羊红细胞的初次免疫应答的抑制作用。
Suppression of the primary immune response in vivo to sheep red blood cells by B-cell mitogens.
作者信息
Diamantstein T, Keppler W, Blitstein-Willinger E
出版信息
Immunology. 1976 Mar;30(3):401-7.
Abstract
Polyacrylic acid (PAAC), lipopolysaccharide (LPS), dextran sulphate (DS) and purified protein derivative of tubercle bacilli (PPD), compounds mitogenic for B lymphocytes in vitro, suppressed the immune response of mice to SRBC in vivo, when injected 4-2 days before immunization. The same compounds enhanced the immune response when injected half an hour before immunization of the animals with a suboptimal antigen dose. A subsequent injection of PAAC given shortly before immunization, abolished the immunosuppressive effect expected by pretreatment of the animals with either PAAC or LPS. A second injection of LPS abolished the immunosuppressive effect of LPS only. The results indicate that when B lymphocytes react with a mitogen in the absence of a particular antigen, they temporarily lose their capacity to respond to antigen.
摘要
聚丙烯酸（PAAC）、脂多糖（LPS）、硫酸葡聚糖（DS）和结核杆菌纯化蛋白衍生物（PPD），这些化合物在体外对B淋巴细胞有丝分裂原性，在免疫前4至2天注射时，可抑制小鼠体内对绵羊红细胞（SRBC）的免疫反应。当在给动物注射次优抗原剂量前半小时注射相同化合物时，可增强免疫反应。在免疫前不久随后注射PAAC，消除了用PAAC或LPS预处理动物预期的免疫抑制作用。第二次注射LPS仅消除了LPS的免疫抑制作用。结果表明，当B淋巴细胞在没有特定抗原的情况下与有丝分裂原反应时，它们会暂时失去对抗原的反应能力。
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Mitogens as probes for immunocyte activation and cellular cooperation.有丝分裂原作为免疫细胞激活和细胞协作的探针。
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