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1
Suppression of the primary immune response in vivo to sheep red blood cells by B-cell mitogens.B细胞有丝分裂原对体内针对绵羊红细胞的初次免疫应答的抑制作用。
Immunology. 1976 Mar;30(3):401-7.
2
Effects of mitogens for mouse B lymphocytes on chicken lymphoid cells.小鼠B淋巴细胞有丝分裂原对鸡淋巴细胞的作用。
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3
Suppressive effect of interferon on the humoral immune response to sheep red blood cells in mice.干扰素对小鼠针对绵羊红细胞的体液免疫反应的抑制作用。
J Immunol. 1974 Oct;113(4):1319-25.
4
Antibody-coated sheep erythrocytes suppress the ability of polyclonal B-cell activators to induce plaque-forming cells against sheep erythrocytes.抗体包被的绵羊红细胞可抑制多克隆B细胞激活剂诱导针对绵羊红细胞的噬斑形成细胞的能力。
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5
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6
Modulation of immune response by bacterial lipopolysaccharide (LPS): multifocal effects of LPS-induced suppression of the primary antibody response to a T-dependent antigen.细菌脂多糖（LPS）对免疫反应的调节：LPS诱导对T细胞依赖性抗原的初次抗体反应抑制的多焦点效应
J Immunol. 1978 Dec;121(6):2340-6.
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8
[Cellular kinetics of the primary immune response after application of phytohemagglutinin].[应用植物血凝素后初次免疫反应的细胞动力学]
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9
Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen.脂多糖诱导对胸腺依赖性抗原的初次免疫应答抑制。
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10
Mechanism of the suppressive effect of interferon on antibody synthesis in vivo.干扰素对体内抗体合成抑制作用的机制。
J Immunol. 1975 Apr;114(4):1323-8.

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Suppression of cell-mediated and humoral immune responses by an interleukin-2-immunoglobulin fusion protein in mice.白细胞介素-2-免疫球蛋白融合蛋白对小鼠细胞介导免疫反应和体液免疫反应的抑制作用
J Clin Invest. 1996 Mar 1;97(5):1204-10. doi: 10.1172/JCI118534.
3
Humoral suppression in Trypanosoma cruzi infection in relation to the timing of antigen presentation.克氏锥虫感染中体液抑制与抗原呈递时间的关系。
Z Parasitenkd. 1980;64(1):85-95. doi: 10.1007/BF00927059.
4
In vitro induction of lymphocyte responsiveness by a Strongylus vulgaris-derived mitogen.由普通圆线虫衍生的促细胞分裂剂在体外诱导淋巴细胞反应性
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Non-specific inhibitory processes of immunological and mitogenic cellular responses.免疫和有丝分裂细胞反应的非特异性抑制过程。
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6
Polyclonal B cell activation, circulating immune complexes and autoimmunity in human american visceral leishmaniasis.人类美洲内脏利什曼病中的多克隆B细胞激活、循环免疫复合物与自身免疫
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7
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Pathological expression of idiotypic interactions: immune complexes and cryoglobulins.独特型相互作用的病理表现：免疫复合物与冷球蛋白
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9
Induction of prostaglandin synthesis-dependent suppressor cells with endotoxin: occurrence in patients with thermal injuries.内毒素诱导前列腺素合成依赖性抑制细胞：在热损伤患者中的出现情况。
J Clin Immunol. 1983 Apr;3(2):142-50. doi: 10.1007/BF00915485.
10
Adjuvant effect of bacterial LPS and/or alum precipitation in responses to polysaccharide and protein antigens.细菌脂多糖和/或明矾沉淀在对多糖和蛋白质抗原反应中的佐剂效应。
Immunology. 1984 Dec;53(4):827-36.

本文引用的文献

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Antigenic competition: cellular or humoral.抗原竞争：细胞性或体液性。
Science. 1967 Oct 27;158(3800):512-4. doi: 10.1126/science.158.3800.512.
2
Effects of RES "blockade" on antibody-formation. I. Suppressed cellular and humoral haemolysin responses in mice injected with carbon particles.白藜芦醇“阻断”对抗体形成的影响。I. 对注射碳颗粒的小鼠细胞和体液溶血素反应的抑制作用
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Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
4
The primary immune response in mice. I. The enhancement and suppression of hemolysin production by a bacterial endotoxin.小鼠的初次免疫反应。I. 细菌内毒素对溶血素产生的增强和抑制作用。
J Exp Med. 1968 Jun 1;127(6):1087-107. doi: 10.1084/jem.127.6.1087.
5
Stimulation of humoral antibody formation by polyanions. II. The influence of sulfate esters of polymers on the immune response in mice.多聚阴离子对体液抗体形成的刺激作用。II. 聚合物硫酸酯对小鼠免疫反应的影响。
Eur J Immunol. 1971 Nov;1(5):340-3. doi: 10.1002/eji.1830010507.
6
Stimulation of humoral antibody formation by polyanions. I. The effect of polyacrylic acid on the primary immune response in mice immunized with sheep red blood cells.多聚阴离子对体液抗体形成的刺激作用。I. 聚丙烯酸对用绵羊红细胞免疫的小鼠初次免疫反应的影响。
Eur J Immunol. 1971 Nov;1(5):335-40. doi: 10.1002/eji.1830010506.
7
The use of bacterial lipopolysaccharides to show that two signals are required for the induction of antibody synthesis.利用细菌脂多糖来表明抗体合成的诱导需要两个信号。
J Exp Med. 1973 Sep 1;138(3):699-714. doi: 10.1084/jem.138.3.699.
8
Differentiation of B cells: sequential appearance of responsiveness to polyclonal activators.B细胞的分化：对多克隆激活剂反应性的顺序出现。
Scand J Immunol. 1974;3(4):413-21. doi: 10.1111/j.1365-3083.1974.tb01274.x.
9
Polyanions and lipopolysaccharide acts on different subpopulations of B cells.聚阴离子和脂多糖作用于B细胞的不同亚群。
Nature. 1974 Aug 16;250(467):596-7. doi: 10.1038/250596a0.
10
Mitogens as probes for immunocyte activation and cellular cooperation.有丝分裂原作为免疫细胞激活和细胞协作的探针。
Transplant Rev. 1972;11:131-77. doi: 10.1111/j.1600-065x.1972.tb00048.x.

B细胞有丝分裂原对体内针对绵羊红细胞的初次免疫应答的抑制作用。

Suppression of the primary immune response in vivo to sheep red blood cells by B-cell mitogens.

作者信息

Diamantstein T, Keppler W, Blitstein-Willinger E

出版信息

Immunology. 1976 Mar;30(3):401-7.

PMID:767254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445173/
Abstract

Polyacrylic acid (PAAC), lipopolysaccharide (LPS), dextran sulphate (DS) and purified protein derivative of tubercle bacilli (PPD), compounds mitogenic for B lymphocytes in vitro, suppressed the immune response of mice to SRBC in vivo, when injected 4-2 days before immunization. The same compounds enhanced the immune response when injected half an hour before immunization of the animals with a suboptimal antigen dose. A subsequent injection of PAAC given shortly before immunization, abolished the immunosuppressive effect expected by pretreatment of the animals with either PAAC or LPS. A second injection of LPS abolished the immunosuppressive effect of LPS only. The results indicate that when B lymphocytes react with a mitogen in the absence of a particular antigen, they temporarily lose their capacity to respond to antigen.

摘要

聚丙烯酸（PAAC）、脂多糖（LPS）、硫酸葡聚糖（DS）和结核杆菌纯化蛋白衍生物（PPD），这些化合物在体外对B淋巴细胞有丝分裂原性，在免疫前4至2天注射时，可抑制小鼠体内对绵羊红细胞（SRBC）的免疫反应。当在给动物注射次优抗原剂量前半小时注射相同化合物时，可增强免疫反应。在免疫前不久随后注射PAAC，消除了用PAAC或LPS预处理动物预期的免疫抑制作用。第二次注射LPS仅消除了LPS的免疫抑制作用。结果表明，当B淋巴细胞在没有特定抗原的情况下与有丝分裂原反应时，它们会暂时失去对抗原的反应能力。