Raafat Karim, Aboul-Ela Maha, El-Lakany Abdalla
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University (BAU), Beirut, 115020, Lebanon.
Arch Pharm Res. 2021 Aug;44(8):1-10. doi: 10.1007/s12272-014-0372-y. Epub 2014 Mar 26.
Rheum ribes L., known as Syrian rhubarb, is used in traditional Lebanese folk medicine for the treatment of diabetes. The present study aims to investigate the activities of R. ribes aqueous extract for glucose homeostasis, in vivo antioxidant and diabetic neuropathy protection in mice. The acute and the subacute effects of various doses of R. ribes on blood glucose and in vivo antioxidant activity utilizing serum catalase level (CAT) were studied in alloxan-diabetic mice. The high doses significantly lowered glucose level and increased serum CAT in alloxan-diabetic mice. Pretreatment with the extract prior to alloxination, protected the mice from acquiring diabetes and diabetic neuropathy. Treatment with the extract for 8 weeks alleviated hyperalgesia in diabetic mice. Our findings provide clinicians with promising drugs intended for the management of the symptoms of diabetic complications. The protective activity of R. ribes against acquiring diabetes and diabetic neuropathy might pave the way for preparing a prophylactic treatment for diabetes risk groups.
刺果茶藨子，又称叙利亚大黄，在黎巴嫩传统民间医学中用于治疗糖尿病。本研究旨在探讨刺果茶藨子水提取物对小鼠葡萄糖稳态、体内抗氧化及糖尿病神经病变保护的作用。在四氧嘧啶诱导的糖尿病小鼠中，研究了不同剂量刺果茶藨子对血糖和利用血清过氧化氢酶水平（CAT）评估的体内抗氧化活性的急性和亚急性影响。高剂量显著降低了四氧嘧啶诱导的糖尿病小鼠的血糖水平，并提高了血清CAT。在四氧嘧啶处理前用提取物预处理，可保护小鼠不患糖尿病和糖尿病神经病变。用提取物治疗8周可减轻糖尿病小鼠的痛觉过敏。我们的研究结果为临床医生提供了有望用于管理糖尿病并发症症状的药物。刺果茶藨子对预防糖尿病和糖尿病神经病变的保护作用可能为糖尿病风险人群的预防性治疗铺平道路。
