Boyce Vanessa S, Mendell Lorne M
Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Handb Exp Pharmacol. 2014;220:443-60. doi: 10.1007/978-3-642-45106-5_16.
A major challenge in repairing the injured spinal cord is to assure survival of damaged cells and to encourage regrowth of severed axons. Because neurotrophins are known to affect these processes during development, many experimental approaches to improving function of the injured spinal cord have made use of these agents, particularly Brain derived neurotrophic factor (BDNF) and Neurotrophin-3 (NT-3). More recently, neurotrophins have also been shown to affect the physiology of cells and synapses in the spinal cord. The effect of neurotrophins on circuit performance adds an important dimension to their consideration as agents for repairing the injured spinal cord. In this chapter we discuss the role of neurotrophins in promoting recovery after spinal cord injury from both a structural and functional perspective.
修复受损脊髓面临的一个主要挑战是确保受损细胞存活并促进切断轴突的再生。由于已知神经营养因子在发育过程中会影响这些过程，许多改善受损脊髓功能的实验方法都利用了这些因子，特别是脑源性神经营养因子（BDNF）和神经营养因子-3（NT-3）。最近，神经营养因子还被证明会影响脊髓中细胞和突触的生理学。神经营养因子对神经回路性能的影响为将其视为修复受损脊髓的药物增添了一个重要方面。在本章中，我们将从结构和功能的角度讨论神经营养因子在促进脊髓损伤后恢复中的作用。
