Davis B A
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
J Chromatogr. 1988 Dec 9;433:23-30. doi: 10.1016/s0378-4347(00)80581-2.
The concentrations of urinary phenylacetic, m- and p-hydroxyphenylacetic, mandelic (MA), p-hydroxymandelic, indoleacetic, homovanillic, vanillylmandelic, 5-hydroxyindoleacetic and 3,4-dihydroxyphenylacetic (DOPAC) acids and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) and the concentrations of the above plasma acids (except MA, MHPG and DOPAC) were determined by gas chromatography-mass spectrometry with selected-ion monitoring at the time of receipt of the samples and after three, six and nine months storage at -18 degrees C. The samples were not treated in any way before storage. The concentrations of most of the urinary metabolites declined significantly (analysis of variance) over the nine-month storage period, whereas most of the plasma metabolites did not.
采用气相色谱 - 质谱联用仪并通过选择离子监测模式，在收到样本时以及在 -18℃下储存3个月、6个月和9个月后，测定尿液中苯乙酸、间羟基苯乙酸、对羟基苯乙酸、扁桃酸（MA）、对羟基扁桃酸、吲哚乙酸、高香草酸、香草扁桃酸、5 - 羟基吲哚乙酸和3,4 - 二羟基苯乙酸（DOPAC）以及上述血浆酸（MA、MHPG和DOPAC除外）的浓度。样本在储存前未进行任何处理。在9个月的储存期内，大多数尿液代谢物的浓度显著下降（方差分析），而大多数血浆代谢物的浓度则没有下降。
