Riederer P, Toifl K, Kruzik P
Clin Chim Acta. 1982 Aug 4;123(1-2):27-32. doi: 10.1016/0009-8981(82)90109-7.
Urinary metabolites of catecholamines and indoleamines have been investigated in 16 patients with anorexia nervosa (AN) and 13 controls using a HPLC-method. Vanillic mandelic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, 3,4-dihydroxyphenylacetic acid, 5-hydroxyindole acetic acid and indoleacetic acid were significantly decreased in the pre-treatment phase. In four patients long-term treatment including parenteral and enteral nutrition together with psychological methods resulted in an increase in the levels of these substances and this correlated with increased weight gain and urinary creatinine. It is concluded that both central and peripheral disturbances are involved in AN, particularly with regard to biogenic amine metabolism.
使用高效液相色谱法对16例神经性厌食症（AN）患者和13名对照者的儿茶酚胺和吲哚胺的尿液代谢产物进行了研究。在治疗前阶段，香草扁桃酸、3-甲氧基-4-羟基苯乙二醇、高香草酸、3,4-二羟基苯乙酸、5-羟基吲哚乙酸和吲哚乙酸显著降低。4例患者接受包括肠外和肠内营养以及心理方法在内的长期治疗后，这些物质的水平有所升高，且这与体重增加和尿肌酐增加相关。得出的结论是，中枢和外周紊乱均与神经性厌食症有关，尤其是在生物胺代谢方面。
