Webb S R, Okamoto A, Sprent J
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
J Immunogenet. 1988 Feb-Jun;15(1-3):111-20. doi: 10.1111/j.1744-313x.1988.tb00413.x.
We review evidence from this laboratory that T cell recognition of Mlsa determinants is not controlled solely by the alpha-beta T cell receptor (TcR) molecule. We propose a model in which Mlsa recognition reflects a receptor-ligand interaction between two sets of complementary accessory molecules, one molecule (Mlsa) being expressed on B cells and the other (the anti-Mlsa receptor) on T cells; this interaction augments recognition of self class II molecules by the TcR. The biological role of Mls molecules might be to facilitate physiological T-B interaction.
我们回顾了本实验室的证据，即T细胞对Mlsa决定簇的识别并非仅由α-βT细胞受体（TcR）分子控制。我们提出了一个模型，其中Mlsa识别反映了两组互补辅助分子之间的受体-配体相互作用，一种分子（Mlsa）在B细胞上表达，另一种（抗Mlsa受体）在T细胞上表达；这种相互作用增强了TcR对自身II类分子的识别。Mls分子的生物学作用可能是促进生理性T-B相互作用。
