Peck A B
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610.
J Immunogenet. 1988 Feb-Jun;15(1-3):77-85. doi: 10.1111/j.1744-313x.1988.tb00410.x.
Data presented here addressed the question of whether T lymphocyte recognition of Mls determinants is MHC restricted. Using isolated T cell blasts from primary MLCs involving H-2-identical, Mls-disparate strain combinations as responding cell populations in secondary MLCs, and measuring their responses against fresh stimulating cells from different strains, has permitted the study of reactions towards Mls determinants in the presence of MHC antigenic differences. Results strongly suggest that recognition of Mlsc (Mls-2 locus) determinants is H-2 restricted. In contrast, there is still little evidence that the recognition of Mlsa (Mls-1 locus) determinants is H-2 restricted. Furthermore, data are also presented which refute the notion that different H-2 haplotypes possess different abilities to present Mlsa determinants to responding T cells.
此处呈现的数据解决了T淋巴细胞对Mls决定簇的识别是否受MHC限制这一问题。利用来自涉及H-2相同、Mls不同品系组合的原发性混合淋巴细胞培养物（MLCs）的分离T细胞母细胞，作为继发性MLCs中的反应细胞群体，并测量它们对来自不同品系的新鲜刺激细胞的反应，从而得以在存在MHC抗原差异的情况下研究对Mls决定簇的反应。结果有力地表明，对Mlsc（Mls-2位点）决定簇的识别受H-2限制。相比之下，几乎没有证据表明对Mlsa（Mls-1位点）决定簇的识别受H-2限制。此外，还给出了一些数据，这些数据驳斥了不同H-2单倍型向反应性T细胞呈递Mlsa决定簇的能力不同这一观点。
