a Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard , Hamdard Nagar , New Delhi , India and.
b Khalsa College of Pharmacy , Amritsar , Punjab , India .
Drug Deliv. 2015;22(6):691-700. doi: 10.3109/10717544.2014.898110. Epub 2014 Mar 27.
Nanostructured lipid carrier (NLCs) is the second generation solid lipid nanoparticles (NPs) made up of physiological, biocompatible, biodegradable, non-sensitizing and non-irritating lipids.
The main objective of this review is to explore the role of NLCs system for delivering drugs by oral route and thus increasing the oral bioavailability.
The present review article highlights the definition and types of NLCs and their importance as colloidal carriers including the production techniques and their formulation. This review article also deals with the fate of lipids used in the NLCs formulation and the NLCs toxicity.
On the basis of the literature survey done, it was concluded that the NLCs enhances the oral bioavailability of the drug and may decrease the side effects and toxicity of the lipids used in other polymeric NPs as NLCs uses physiological and biodegradable lipids.
纳米结构脂质载体（NLCs）是由生理上相容、可生物降解、非致敏和非刺激性的脂质组成的第二代固体脂质纳米颗粒（NPs）。
本综述的主要目的是探讨 NLCs 系统通过口服途径给药的作用，从而提高口服生物利用度。
本文重点介绍了 NLCs 的定义和类型及其作为胶体载体的重要性，包括生产技术及其配方。本文还涉及 NLCs 配方中使用的脂质的命运和 NLCs 的毒性。
根据文献调查，NLCs 可以提高药物的口服生物利用度，并可能降低其他聚合物 NPs 中使用的脂质的副作用和毒性，因为 NLCs 使用生理和可生物降解的脂质。
