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The Trp64Arg β3-adrenergic receptor gene polymorphism is associated with endothelium-dependent vasodilatation.

作者信息

Xifra G, Castro A, Ortega F J, Ricart W, Fernández-Real J M

机构信息

1] Department of Diabetes, Endocrinology and Nutrition, Hospital of Girona Dr Josep Trueta, Girona, Spain [2] CIBERobn Fisiopatologia de la Obesidad y Nutrición, Hospital Clínico Universitario, Santiago de Compostela, Choupana, Spain.

1] CIBERobn Fisiopatologia de la Obesidad y Nutrición, Hospital Clínico Universitario, Santiago de Compostela, Choupana, Spain [2] Department of Internal Medicine, Hospital Josep Trueta, Girona, Spain.

出版信息

J Hum Hypertens. 2015 Feb;29(2):134-5. doi: 10.1038/jhh.2014.17. Epub 2014 Mar 27.

DOI:10.1038/jhh.2014.17
PMID:24670327
Abstract
摘要

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本文引用的文献

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Roles of beta2- and beta3-adrenoceptor polymorphisms in hypertension and metabolic syndrome.β2-和β3-肾上腺素能受体多态性在高血压和代谢综合征中的作用。
Int J Hypertens. 2010 Oct 21;2010:832821. doi: 10.4061/2010/832821.
2
Polymorphism Trp64Arg of beta 3 adrenoreceptor gene: allelic frequencies and influence on insulin resistance in a multicenter study of Castilla-León.β3肾上腺素能受体基因Trp64Arg多态性：卡斯蒂利亚-莱昂多中心研究中的等位基因频率及其对胰岛素抵抗的影响
Nutr Hosp. 2010 Mar-Apr;25(2):299-303.
3
Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling.
肾上腺素对内皮型一氧化氮合酶的调节：RAC1和β3-肾上腺素能受体在内皮型一氧化氮信号传导中的作用
J Biol Chem. 2007 Nov 9;282(45):32719-29. doi: 10.1074/jbc.M706815200. Epub 2007 Sep 12.
4
Alpha defensins 1, 2, and 3: potential roles in dyslipidemia and vascular dysfunction in humans.α-防御素1、2和3：在人类血脂异常和血管功能障碍中的潜在作用。
Arterioscler Thromb Vasc Biol. 2007 May;27(5):1166-71. doi: 10.1161/ATVBAHA.106.138594. Epub 2007 Feb 15.
5
Gly16 + Glu27 beta2-adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans.Gly16 + Glu27β2 - 肾上腺素能受体基因多态性导致人类前臂对精神压力和握力的血流反应增加。
J Appl Physiol (1985). 2005 Mar;98(3):787-94. doi: 10.1152/japplphysiol.00503.2004.
6
Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization.内皮β3-肾上腺素能受体通过一氧化氮和内皮依赖性超极化介导人冠状动脉微血管的血管舒张。
Circulation. 2004 Aug 24;110(8):948-54. doi: 10.1161/01.CIR.0000139331.85766.AF. Epub 2004 Aug 9.
7
Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries.胸痛且冠状动脉造影正常患者左前降支冠状动脉对乙酰胆碱的反应
Am J Cardiol. 2003 Dec 15;92(12):1394-8. doi: 10.1016/j.amjcard.2003.08.043.
8
Vascular smooth muscle cell apoptosis in atherosclerosis.动脉粥样硬化中的血管平滑肌细胞凋亡
Int J Exp Pathol. 1999 Aug;80(4):197-203. doi: 10.1046/j.1365-2613.1999.00125.x.
9
Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: association with mild gestational diabetes mellitus.孕期β3-肾上腺素能受体基因Trp64Arg多态性：与轻度妊娠期糖尿病的关联
J Clin Endocrinol Metab. 1999 May;84(5):1695-9. doi: 10.1210/jcem.84.5.5650.
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J Clin Invest. 1998 Feb 1;101(3):584-7. doi: 10.1172/JCI512.