酪蛋白磷酸肽-无定形磷酸钙溶液预防牙釉质脱矿的效果

[Effect of casein osphopeptide-amorphous calcium phosphate solution in preventing enamel demineralization].

作者信息

Long Baojun, Chen Ke, Zhang Dongjie, Li Yunpeng

机构信息

Department of Stomatology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China. E-mail:

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2014 Mar;34(3):430-3.

PMID:24670465

Abstract

OBJECTIVE

To evaluate the effects of casein osphopeptide-amorphous calcium phosphate (CPP-ACP) in preventing enamel demineralization.

METHODS

Enamel blocks were prepared from premolars extracted from orthodontic patients. The specimens were treated for 30 min daily for 7 days with one of the following agents: deionized water (negative control), CPP-ACP paste, and NaF solutions (positive controls) (0.2% and 2%). After the treatments, the specimens were immersed in a demineralizing solution (pH 4.5) for 7 days. The morphology and depth of the lesion were observed using scanning electron microscopy, and the content of Ca, P, Mg in the demineralized enamel was measured by electron probe micro-analyzer.

RESULTS

The demineralization rates in all the treatment groups were significantly smaller than those in the control group after 7 days of demineralization.

CONCLUSION

The application of CPP-ACP to the enamel surfaces can inhibit enamel demineralization with an equivalent effect to 0.2% NaF.

摘要

目的

评估酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）预防牙釉质脱矿的效果。

方法

从正畸患者拔除的前磨牙制备牙釉质块。将标本每天用以下试剂之一处理30分钟，共7天：去离子水（阴性对照）、CPP-ACP糊剂和NaF溶液（阳性对照）（0.2%和2%）。处理后，将标本浸入脱矿溶液（pH 4.5）中7天。使用扫描电子显微镜观察病变的形态和深度，并用电子探针微分析仪测量脱矿牙釉质中钙、磷、镁的含量。