Zhao Nan, Workman Benjamin, Zhu Donghui
Department of Chemical, Biological and Bio-Engineering, NSF Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA.
Int J Mol Sci. 2014 Mar 25;15(4):5263-76. doi: 10.3390/ijms15045263.
Magnesium (Mg) alloys are promising scaffolds for the next generation of cardiovascular stents because of their better biocompatibility and biodegradation compared to traditional metals. However, insufficient mechanical strength and high degradation rate are still the two main limitations for Mg materials. Hydrofluoric acid (HF) treatment and collagen coating were used in this research to improve the endothelialization of two rare earth-based Mg alloys. Results demonstrated that a nanoporous film structure of fluoride with thickness of ~20 µm was formed on the Mg material surface, which improved the corrosion resistance. Primary human coronary artery endothelial cells (HCAECs) had much better attachment, spreading, growth and proliferation (the process of endothelialization) on HF-treated Mg materials compared to bare- or collagen-coated ones.
镁（Mg）合金因其与传统金属相比具有更好的生物相容性和生物降解性，有望成为下一代心血管支架的支架材料。然而，机械强度不足和降解速率高仍是镁材料的两个主要局限性。本研究采用氢氟酸（HF）处理和胶原蛋白涂层来改善两种稀土基镁合金的内皮化。结果表明，在镁材料表面形成了厚度约为20 µm的纳米多孔氟化物膜结构，提高了耐腐蚀性。与未处理或胶原蛋白涂层的镁材料相比，原代人冠状动脉内皮细胞（HCAECs）在经HF处理的镁材料上具有更好的附着、铺展、生长和增殖（内皮化过程）。
