Bing R F, Heagerty A M, Swales J D
Department of Medicine, University of Leicester, England.
J Cardiovasc Pharmacol. 1988;12 Suppl 3:S110-3.
It has been postulated that changes in the fatty acid component of cell membrane phospholipids play an important role in cell membrane ion handling. To test this hypothesis, we have administered the polyunsaturated fatty acid linoleic acid (as 4 g daily of safflower oil) to 25 normotensive volunteers in a double-blind crossover trial for 4 weeks. There was a significant decrease in leucocyte ionised calcium at the end of active treatment compared with the end of placebo period. There was no difference in subjects with and without a family history of hypertension and there was no significant effect upon blood pressure. It is concluded that cell membrane fatty acids play a role in the regulation of intracellular calcium in the leucocyte, and perhaps therefore in other tissues.
据推测，细胞膜磷脂脂肪酸成分的变化在细胞膜离子处理中起重要作用。为了验证这一假设，我们在一项为期4周的双盲交叉试验中，给25名血压正常的志愿者服用了多不饱和脂肪酸亚油酸（以每天4克红花油的形式）。与安慰剂期结束时相比，积极治疗结束时白细胞离子钙显著降低。有高血压家族史和无高血压家族史的受试者之间没有差异，且对血压没有显著影响。结论是，细胞膜脂肪酸在白细胞细胞内钙的调节中起作用，因此可能在其他组织中也起作用。
