Li Jianing, Li Yanan, Zhang Shuang, Shi He
Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Jiahe Clinic, Jinan, Shandong Province, China.
Medicine (Baltimore). 2025 Sep 5;104(36):e44135. doi: 10.1097/MD.0000000000044135.
Serum uric acid (SUA) levels are linked to increased disease vulnerability and higher recurrence rates; however, the exact causal relationships are elusive. Despite the prevalent hyperuricemia in East Asian populations, comprehensive research on the intricate association between SUA levels and disease is lacking. To address this, a study utilizing a 2-sample Mendelian randomization (MR) approach was conducted in East Asian populations. This study utilized MR to explore the correlation between SUA levels and various disorders, employing data from genome-wide association studies and multiple independent single-nucleotide polymorphism. Multiple single-nucleotide polymorphisms were applied to assess the causal relationship between SUA and other diseases. Methodologies encompassed inverse-variance weighting, MR-Egger regression, and weighted median analysis. This study revealed that SUA increases the risk of coronary artery disease (β = 0.197 mm, 95% CI: 0.084-0.31 mm, P = .001) but decreases the risk of rheumatoid arthritis (β = -0.172 mm, 95% CI: -0.302 to -0.043 mm, P = .009). It also increases diastolic blood pressure, serum creatinine, eosinophil count, relative wall thickness, posterior wall thickness, and interventricular septum thickness and decreases high-density lipoprotein cholesterol and the estimated glomerular filtration rate. These findings suggest that SUA may be a potential risk factor for certain diseases. Research indicates a strong correlation between SUA and illnesses, particularly metabolism and rheumatoid arthritis, in East Asians. This study underscores the necessity of monitoring SUA levels to prevent further illnesses and prompt action to address the growing burden of SUA in the East Asian populations.
血清尿酸（SUA）水平与疾病易感性增加和复发率升高有关；然而，确切的因果关系尚不清楚。尽管东亚人群中高尿酸血症普遍存在，但缺乏关于SUA水平与疾病之间复杂关联的全面研究。为了解决这一问题，在东亚人群中进行了一项采用双样本孟德尔随机化（MR）方法的研究。本研究利用MR，采用全基因组关联研究数据和多个独立单核苷酸多态性，探索SUA水平与各种疾病之间的相关性。应用多个单核苷酸多态性来评估SUA与其他疾病之间的因果关系。方法包括逆方差加权、MR-Egger回归和加权中位数分析。本研究表明，SUA会增加冠状动脉疾病的风险（β = 0.197 mm，95%CI：0.084 - 0.31 mm，P = .001），但会降低类风湿性关节炎的风险（β = -0.172 mm，95%CI：-0.302至-0.043 mm，P = .009）。它还会增加舒张压、血清肌酐、嗜酸性粒细胞计数、相对壁厚、后壁厚度和室间隔厚度，并降低高密度脂蛋白胆固醇和估计肾小球滤过率。这些发现表明，SUA可能是某些疾病的潜在危险因素。研究表明，在东亚人群中，SUA与疾病，尤其是代谢和类风湿性关节炎之间存在密切关联。本研究强调了监测SUA水平以预防进一步疾病的必要性，并促使采取行动应对东亚人群中不断增加的SUA负担。
