Division of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
BMC Cardiovasc Disord. 2024 Nov 1;24(1):614. doi: 10.1186/s12872-024-04287-y.
Both serum uric acid (SUA) levels and body mass index (BMI) are recognized as important risk factors for hypertension. The current study aimed to investigate the interaction effects between SUA levels and overweight (defined as BMI ≥ 24 kg/m in Chinese) on the incidence of hypertension among Chinese adults.
1124 hypertensive participants and 7283 non-hypertensive participants, extracted from the China Health and Nutrition Survey (CHNS), were analyzed. Participants were categorized based on their SUA levels and BMI, to investigate the interaction effects between SUA levels and overweight on hypertension.
In comparison with the reference group (BMI < 24 kg/m and in the 1st quintile of SUA), multivariable adjusted analysis demonstrated that the odds ratio (OR) (95% confidence interval, 95% CI) of hypertension for participants with overweight alone was 2.18 (1.41-3.37); for elevated SUA levels alone, the ORs (95% CIs) were 1.57 (1.08-2.30), 1.84 (1.24-2.74), 2.21 (1.47-3.32), and 2.48 (1.55-3.96) across SUA quintiles; and for the combined effect of higher SUA levels and overweight, the ORs (95% CIs) were 3.25 (2.19-4.82), 3.73 (2.51-5.55), 5.17 (3.42-7.80), and 6.21 (4.01-9.60). The relative excess risk due to interaction (RERI) was 3.26 (1.43-5.09) at the 5th quintile of SUA, indicating the presence of additive interaction between overweight and SUA levels on hypertension.
Interaction between SUA levels and overweight on hypertension exists specifically at the highest quintile (Q5, > 6.39 mg/dL) of SUA among Chinese adults. Therefore, strategies to lower SUA levels could be considered as a potential approach to mitigate hypertension risk in overweight individuals within this specific subgroup.
血清尿酸（SUA）水平和体重指数（BMI）均被认为是高血压的重要危险因素。本研究旨在探讨中国成年人中 SUA 水平与超重（BMI≥24kg/m 定义为超重）之间的交互作用对高血压发病的影响。
从中国健康与营养调查（CHNS）中提取了 1124 名高血压患者和 7283 名非高血压患者进行分析。根据 SUA 水平和 BMI 将参与者分为不同组别，以探讨 SUA 水平和超重之间的交互作用对高血压的影响。
与参考组（BMI<24kg/m 且 SUA 处于第 1 五分位）相比，多变量调整分析显示，仅超重的参与者发生高血压的比值比（OR）（95%置信区间，95%CI）为 2.18（1.41-3.37）；仅升高的 SUA 水平的 ORs（95% CIs）分别为 1.57（1.08-2.30）、1.84（1.24-2.74）、2.21（1.47-3.32）和 2.48（1.55-3.96），跨越 SUA 五分位数；对于 SUA 水平升高和超重的联合效应，ORs（95% CIs）分别为 3.25（2.19-4.82）、3.73（2.51-5.55）、5.17（3.42-7.80）和 6.21（4.01-9.60）。SUA 五分位数的交互超额相对危险度（RERI）为 3.26（1.43-5.09），表明超重和 SUA 水平对高血压存在附加交互作用。
在中国成年人中，SUA 水平与超重对高血压的交互作用仅在 SUA 的最高五分位数（Q5，>6.39mg/dL）存在。因此，降低 SUA 水平的策略可能被视为减轻该特定亚组中超重个体高血压风险的一种潜在方法。
