Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
J Pharmacol Sci. 2014;124(4):514-7. doi: 10.1254/jphs.13249sc. Epub 2014 Mar 27.
Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy.
奥沙利铂是一种基于铂的化疗药物，几乎所有患者在输注过程中或输注后数小时内都会因寒冷而引发急性周围神经病。我们最近报道，奥沙利铂单次给药后 2 小时可诱导小鼠产生冷超敏反应。在这项研究中，我们检查了标准镇痛剂是否可以缓解奥沙利铂引起的急性冷超敏反应。加巴喷丁、曲马多、美西律和葡萄糖酸钙显著抑制，而吗啡和米那普仑则降低了急性冷超敏反应，而双氯芬酸和阿米替林则没有效果。这些结果表明，加巴喷丁、曲马多、美西律和葡萄糖酸钙对奥沙利铂引起的急性周围神经病有效。
