Kawashiri Takehiro, Mine Keisuke, Kobayashi Daisuke, Inoue Mizuki, Ushio Soichiro, Uchida Mayako, Egashira Nobuaki, Shimazoe Takao
Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Department of Pharmacy, Okayama University Hospital, Okayama 700-8558, Japan.
Int J Mol Sci. 2021 Jan 30;22(3):1393. doi: 10.3390/ijms22031393.
Oxaliplatin is an essential drug in the chemotherapy of colorectal, gastric, and pancreatic cancers, but it frequently causes peripheral neuropathy as a dose-limiting factor. So far, animal models of oxaliplatin-induced peripheral neuropathy have been established. The mechanisms of development of neuropathy induced by oxaliplatin have been elucidated, and many drugs and agents have been proven to have neuroprotective effects in basic studies. In addition, some of these drugs have been validated in clinical studies for their inhibitory effects on neuropathy. In this review, we summarize the basic and clinical evidence for the therapeutic effects of oxaliplatin. In basic research, there are many reports of neuropathy inhibitors that target oxidative stress, inflammatory response, sodium channel, transient receptor potential (TRP) channel, glutamate nervous system, and monoamine nervous system. Alternatively, very few drugs have clearly demonstrated the efficacy for oxaliplatin-induced peripheral neuropathy in clinical trials. It is important to activate translational research in order to translate basic research into clinical research.
奥沙利铂是结直肠癌、胃癌和胰腺癌化疗中的一种关键药物，但它经常导致周围神经病变，成为剂量限制因素。到目前为止，已经建立了奥沙利铂诱导的周围神经病变的动物模型。奥沙利铂诱导的神经病变的发病机制已经阐明，并且许多药物和制剂在基础研究中已被证明具有神经保护作用。此外，其中一些药物在临床研究中已被证实对神经病变具有抑制作用。在这篇综述中，我们总结了奥沙利铂治疗效果的基础和临床证据。在基础研究中，有许多关于针对氧化应激、炎症反应、钠通道、瞬时受体电位（TRP）通道、谷氨酸神经系统和单胺神经系统的神经病变抑制剂的报道。或者，在临床试验中，很少有药物能明确证明对奥沙利铂诱导的周围神经病变有效。激活转化研究以便将基础研究转化为临床研究很重要。
