单胺氧化酶A（MAOA）基因分型与男性空间能力相关的证据。
Evidence of MAOA genotype involvement in spatial ability in males.
作者信息
Mueller Sven C, Cornwell Brian R, Grillon Christian, Macintyre Jessica, Gorodetsky Elena, Goldman David, Pine Daniel S, Ernst Monique
机构信息
Department of Experimental Clinical and Health Psychology, Ghent University, 9000 Ghent, Belgium; Section on Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Swinburne University, Melbourne, Hawthorn, VIC 3122, Australia.
出版信息
Behav Brain Res. 2014 Jul 1;267:106-10. doi: 10.1016/j.bbr.2014.03.025. Epub 2014 Mar 23.
Although the monoamine oxidase-A (MAOA) gene has been linked to spatial learning and memory in animal models, convincing evidence in humans is lacking. Performance on an ecologically-valid, virtual computer-based equivalent of the Morris Water Maze task was compared between 28 healthy males with the low MAOA transcriptional activity and 41 healthy age- and IQ-matched males with the high MAOA transcriptional activity. The results revealed consistently better performance (reduced heading error, shorter path length, and reduced failed trials) for the high MAOA activity individuals relative to the low activity individuals. By comparison, groups did not differ on pre-task variables or strategic measures such as first-move latency. The results provide novel evidence of MAOA gene involvement in human spatial navigation using a virtual analogue of the Morris Water Maze task.
尽管单胺氧化酶A（MAOA）基因在动物模型中与空间学习和记忆有关，但在人类中缺乏确凿证据。研究比较了28名MAOA转录活性低的健康男性和41名年龄及智商匹配、MAOA转录活性高的健康男性在基于计算机虚拟的、生态效度良好的莫里斯水迷宫任务等效任务中的表现。结果显示，相对于低活性个体，高MAOA活性个体的表现始终更好（航向误差减小、路径长度缩短、失败试验减少）。相比之下，两组在任务前变量或诸如首次移动潜伏期等策略性指标上没有差异。这些结果为MAOA基因参与人类使用莫里斯水迷宫任务虚拟模拟进行空间导航提供了新证据。
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