Huber Alexa, Lui Fausta, Duzzi Davide, Pagnoni Giuseppe, Porro Carlo Adolfo
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
PLoS One. 2014 Mar 26;9(3):e93187. doi: 10.1371/journal.pone.0093187. eCollection 2014.
Little is known about the neural bases of hypnotic suggestibility, a cognitive trait referring to the tendency to respond to hypnotic suggestions. In the present magnetic resonance imaging study, we performed regression analyses to assess hypnotic suggestibility-related differences in local gray matter volume, using voxel-based morphometry, and in waking resting state functional connectivity of 10 resting state networks, in 37 healthy women. Hypnotic suggestibility was positively correlated with gray matter volume in portions of the left superior and medial frontal gyri, roughly overlapping with the supplementary and pre-supplementary motor area, and negatively correlated with gray matter volume in the left superior temporal gyrus and insula. In the functional connectivity analysis, hypnotic suggestibility was positively correlated with functional connectivity between medial posterior areas, including bilateral posterior cingulate cortex and precuneus, and both the lateral visual network and the left fronto-parietal network; a positive correlation was also found with functional connectivity between the executive-control network and a right postcentral/parietal area. In contrast, hypnotic suggestibility was negatively correlated with functional connectivity between the right fronto-parietal network and the right lateral thalamus. These findings demonstrate for the first time a correlation between hypnotic suggestibility, the structural features of specific cortical regions, and the functional connectivity during the normal resting state of brain structures involved in imagery and self-monitoring activity.
关于催眠易感性的神经基础，人们了解甚少。催眠易感性是一种认知特质，指的是对催眠暗示作出反应的倾向。在本磁共振成像研究中，我们进行了回归分析，以评估37名健康女性在局部灰质体积方面与催眠易感性相关的差异（使用基于体素的形态测量法），以及在10个静息态网络的清醒静息态功能连接方面的差异。催眠易感性与左侧额上回和额中回部分区域的灰质体积呈正相关，大致与辅助运动区和前辅助运动区重叠，与左侧颞上回和脑岛的灰质体积呈负相关。在功能连接分析中，催眠易感性与内侧后部区域之间的功能连接呈正相关，内侧后部区域包括双侧后扣带回皮质和楔前叶，以及外侧视觉网络和左侧额顶网络；还发现与执行控制网络和右侧中央后回/顶叶区域之间的功能连接呈正相关。相比之下，催眠易感性与右侧额顶网络和右侧外侧丘脑之间的功能连接呈负相关。这些发现首次证明了催眠易感性、特定皮质区域的结构特征以及参与意象和自我监测活动的脑结构在正常静息状态下的功能连接之间的相关性。
