Heck M M, Retz M, Nawroth R
Klinik und Poliklinik für Urologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland,
Urologe A. 2014 Apr;53(4):484-90. doi: 10.1007/s00120-014-3441-4.
A positive lymph node status is a major prognostic factor for tumor recurrence and mortality following radical prostatectomy in prostate cancer patients or radical cystectomy in bladder cancer patients. However, despite having histopathologic negative lymph nodes, a substantial proportion of patient suffers from tumor recurrence within a few years after the operation. Tumor recurrence in node-negative patients may result from hematogeneous or lymphatic metastatic spread which remains undetected by standard clinical or histopathologic examinations. Molecular lymph node analysis is a potential method for detection of lymph node metastases with higher sensitivity and for prognostic risk stratification of patients with histopathologic negative lymph nodes.
淋巴结阳性状态是前列腺癌患者根治性前列腺切除术后或膀胱癌患者根治性膀胱切除术后肿瘤复发和死亡的主要预后因素。然而，尽管组织病理学检查显示淋巴结阴性，但仍有相当一部分患者在术后几年内出现肿瘤复发。淋巴结阴性患者的肿瘤复发可能是由于血行或淋巴转移扩散所致，而标准临床或组织病理学检查无法检测到这些转移。分子淋巴结分析是一种潜在的方法，可用于检测淋巴结转移，提高检测灵敏度，并对组织病理学检查淋巴结阴性的患者进行预后风险分层。
