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[前列腺癌和膀胱癌:骨髓中播散肿瘤细胞的检测]

[Prostate and bladder cancer: detection of disseminated tumor cells in bone marrow].

作者信息

Nawroth R, Weckermann D, Retz M

机构信息

Klinik und Poliklinik für Urologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Deutschland,

出版信息

Urologe A. 2014 Apr;53(4):514-8. doi: 10.1007/s00120-014-3445-0.

DOI:10.1007/s00120-014-3445-0
PMID:24671250
Abstract

The prognosis of prostate and bladder cancer patients is predominantly determined by the detection of distant sites of metastasis. In clinical routine, virtually only lymph node staging is of relevance to determine metastasis. Detection and characterization of disseminated tumor cells in peripheral blood or bone marrow is an additional parameter of prognostic significance. In this article, we will summarize recent progress on the prognostic value of disseminated tumor cells in bone marrow and its translation into routine clinical analysis.

摘要

前列腺癌和膀胱癌患者的预后主要取决于远处转移部位的检测。在临床实践中,实际上只有淋巴结分期与确定转移有关。外周血或骨髓中播散肿瘤细胞的检测和特征分析是另一个具有预后意义的参数。在本文中,我们将总结骨髓中播散肿瘤细胞预后价值的最新进展及其在常规临床分析中的应用。

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[Prostate and bladder cancer: detection of disseminated tumor cells in bone marrow].[前列腺癌和膀胱癌:骨髓中播散肿瘤细胞的检测]
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[Molecular lymph node staging in prostate and bladder cancer].[前列腺癌和膀胱癌的分子淋巴结分期]
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[Detection of lymphovascular invasion in urothelial carcinoma of the bladder through D2-40 immunostaining].通过D2-40免疫染色检测膀胱尿路上皮癌中的淋巴管浸润
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本文引用的文献

1
Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression.在前列腺癌患者的骨髓中,假定癌症干细胞标志物的表达增加与骨转移进展相关。
Prostate. 2013 Dec;73(16):1738-46. doi: 10.1002/pros.22689. Epub 2013 Sep 21.
2
GAS6 receptor status is associated with dormancy and bone metastatic tumor formation.GAS6 受体状态与休眠和骨转移瘤的形成有关。
PLoS One. 2013 Apr 24;8(4):e61873. doi: 10.1371/journal.pone.0061873. Print 2013.
3
Differential expression of matrix metalloproteinase-2 expression in disseminated tumor cells and micrometastasis in bone marrow of patients with nonmetastatic and metastatic prostate cancer: theoretical considerations and clinical implications-an immunocytochemical study.
非转移性和转移性前列腺癌患者骨髓中播散肿瘤细胞及微转移灶中基质金属蛋白酶-2表达的差异:理论思考与临床意义——一项免疫细胞化学研究
Bone Marrow Res. 2012;2012:259351. doi: 10.1155/2012/259351. Epub 2012 Nov 26.
4
Prostate cancer and parasitism of the bone hematopoietic stem cell niche.前列腺癌与骨髓造血干细胞龛的寄生关系
Crit Rev Eukaryot Gene Expr. 2012;22(2):131-48. doi: 10.1615/critreveukargeneexpr.v22.i2.50.
5
The prostate cancer bone marrow niche: more than just 'fertile soil'.前列腺癌骨髓微环境:不只是“肥沃土壤”。
Asian J Androl. 2012 May;14(3):423-7. doi: 10.1038/aja.2011.164. Epub 2012 Feb 27.
6
Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype.前列腺癌转移细胞可指示造血干细胞和祖细胞调节骨表型。
Mol Cancer Res. 2012 Mar;10(3):282-92. doi: 10.1158/1541-7786.MCR-11-0404. Epub 2012 Jan 12.
7
Utility of urothelial mRNA markers in blood for staging and monitoring bladder cancer.尿路上皮 mRNA 标志物在血液中用于膀胱癌的分期和监测。
Urology. 2012 Jan;79(1):240.e9-15. doi: 10.1016/j.urology.2011.09.006. Epub 2011 Nov 4.
8
Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors.造血干细胞龛是治疗骨转移肿瘤的潜在靶点。
Clin Cancer Res. 2011 Sep 1;17(17):5553-8. doi: 10.1158/1078-0432.CCR-10-2505. Epub 2011 Jun 15.
9
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow.人前列腺癌转移定位于造血干细胞龛,在小鼠骨髓中建立立足点。
J Clin Invest. 2011 Apr;121(4):1298-312. doi: 10.1172/JCI43414. Epub 2011 Mar 23.
10
Long-term follow-up of bladder cancer patients with disseminated tumour cells in bone marrow.膀胱癌骨髓播散肿瘤细胞患者的长期随访。
Eur Urol. 2011 Aug;60(2):231-8. doi: 10.1016/j.eururo.2010.12.014. Epub 2010 Dec 22.