前列腺癌骨髓微环境：不只是“肥沃土壤”。
The prostate cancer bone marrow niche: more than just 'fertile soil'.
机构信息
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.
出版信息
Asian J Androl. 2012 May;14(3):423-7. doi: 10.1038/aja.2011.164. Epub 2012 Feb 27.
Abstract
The hematopoietic stem cell (HSC) niche in the bone marrow has been studied extensively over the past few decades, yet the bone marrow microenvironment that supports the growth of metastatic prostate cancer (PCa) has only been recently considered to be a specialized 'niche' as well. New evidence supports the fact that disseminated tumor cells (DTCs) of PCa actually target the HSC niche, displace the occupant HSCs and take up residence in the pre-existing niche space. This review describes some of the evidence and mechanisms by which DTCs act as molecular parasites of the HSC niche. Furthermore, the interactions between DTCs, HSCs and the niche may provide new targets for niche-directed therapy, as well as insight into the perplexing clinical manifestations of metastatic PCa disease.
摘要
在过去的几十年中，人们对骨髓中的造血干细胞（HSC）龛进行了广泛的研究，但直到最近，人们才开始认为支持转移性前列腺癌（PCa）生长的骨髓微环境也是一个专门的“龛”。新的证据支持这样一个事实，即 PCa 的播散性肿瘤细胞（DTC）实际上靶向 HSC 龛，取代占据者 HSCs 并占据预先存在的龛空间。这篇综述描述了 DTC 作为 HSC 龛的分子寄生物的一些证据和机制。此外，DTC、HSC 和龛之间的相互作用可能为龛定向治疗提供新的靶点，并深入了解转移性 PCa 疾病令人费解的临床表现。
相似文献
1
The prostate cancer bone marrow niche: more than just 'fertile soil'.前列腺癌骨髓微环境：不只是“肥沃土壤”。
Asian J Androl. 2012 May;14(3):423-7. doi: 10.1038/aja.2011.164. Epub 2012 Feb 27.
2
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow.人前列腺癌转移定位于造血干细胞龛，在小鼠骨髓中建立立足点。
J Clin Invest. 2011 Apr;121(4):1298-312. doi: 10.1172/JCI43414. Epub 2011 Mar 23.
3
The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer.骨髓微环境控制播散性前列腺癌的癌症干细胞表型。
Oncotarget. 2016 Jul 5;7(27):41217-41232. doi: 10.18632/oncotarget.9251.
4
Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors.造血干细胞龛是治疗骨转移肿瘤的潜在靶点。
Clin Cancer Res. 2011 Sep 1;17(17):5553-8. doi: 10.1158/1078-0432.CCR-10-2505. Epub 2011 Jun 15.
5
Prostate cancer and parasitism of the bone hematopoietic stem cell niche.前列腺癌与骨髓造血干细胞龛的寄生关系
Crit Rev Eukaryot Gene Expr. 2012;22(2):131-48. doi: 10.1615/critreveukargeneexpr.v22.i2.50.
6
Biochemical Changes in the Niche Following Tumor Cell Invasion.肿瘤细胞侵袭后生态位中的生化变化。
J Cell Biochem. 2017 Aug;118(8):1956-1964. doi: 10.1002/jcb.25843. Epub 2017 Apr 18.
7
Parallels between hematopoietic stem cell and prostate cancer disseminated tumor cell regulation.造血干细胞与前列腺癌播散肿瘤细胞调控的相似性。
Bone. 2019 Feb;119:82-86. doi: 10.1016/j.bone.2018.02.025. Epub 2018 Feb 26.
8
Mapping bone marrow niches of disseminated tumor cells.绘制弥散性肿瘤细胞的骨髓龛位。
Sci China Life Sci. 2017 Oct;60(10):1125-1132. doi: 10.1007/s11427-017-9180-5. Epub 2017 Oct 11.
9
Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype.前列腺癌转移细胞可指示造血干细胞和祖细胞调节骨表型。
Mol Cancer Res. 2012 Mar;10(3):282-92. doi: 10.1158/1541-7786.MCR-11-0404. Epub 2012 Jan 12.
10
Emerging Players in Prostate Cancer-Bone Niche Communication.前列腺癌骨龛通讯中的新兴参与者。
Trends Cancer. 2021 Feb;7(2):112-121. doi: 10.1016/j.trecan.2020.09.006. Epub 2020 Oct 24.
引用本文的文献
1
The Tight Relationship Between the Tumoral Microenvironment and Radium-223.肿瘤微环境与镭-223之间的紧密关系
Biomedicines. 2025 Feb 12;13(2):456. doi: 10.3390/biomedicines13020456.
2
Prostate Cancer Bone Metastasis: Molecular Mechanisms of Tumor and Bone Microenvironment.前列腺癌骨转移：肿瘤与骨微环境的分子机制
Cancer Manag Res. 2025 Feb 1;17:219-237. doi: 10.2147/CMAR.S495169. eCollection 2025.
3
Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis.趋化因子和细胞因子在前列腺癌骨转移中的作用。
Curr Osteoporos Rep. 2024 Nov 25;23(1):3. doi: 10.1007/s11914-024-00897-9.
4
Patient-Derived Conditionally Reprogrammed Cells in Prostate Cancer Research.患者来源的条件重编程细胞在前列腺癌研究中的应用。
Cells. 2024 Jun 8;13(12):1005. doi: 10.3390/cells13121005.
5
Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients.自发性破骨细胞生成，晚期腔面A型乳腺癌患者发生骨转移的一个风险因素。
Front Oncol. 2023 Feb 20;13:1073793. doi: 10.3389/fonc.2023.1073793. eCollection 2023.
6
Enzalutamide-induced and PTH1R-mediated TGFBR2 degradation in osteoblasts confers resistance in prostate cancer bone metastases.恩扎卢胺诱导的和 PTH1R 介导的成骨细胞中 TGFBR2 的降解赋予了前列腺癌骨转移中的耐药性。
Cancer Lett. 2022 Jan 28;525:170-178. doi: 10.1016/j.canlet.2021.10.042. Epub 2021 Nov 6.
7
Extracellular Vesicle-Mediated Bone Remodeling and Bone Metastasis: Implications in Prostate Cancer.细胞外囊泡介导的骨重塑和骨转移：在前列腺癌中的意义。
Subcell Biochem. 2021;97:297-361. doi: 10.1007/978-3-030-67171-6_12.
8
Identification of Key Gene Signatures Associated With Bone Metastasis in Castration-Resistant Prostate Cancer Using Co-Expression Analysis.利用共表达分析鉴定去势抵抗性前列腺癌中与骨转移相关的关键基因特征
Front Oncol. 2021 Feb 2;10:571524. doi: 10.3389/fonc.2020.571524. eCollection 2020.
9
Oestrogen and zoledronic acid driven changes to the bone and immune environments: Potential mechanisms underlying the differential anti-tumour effects of zoledronic acid in pre- and post-menopausal conditions.雌激素和唑来膦酸对骨骼及免疫环境的驱动性变化：唑来膦酸在绝经前和绝经后条件下产生不同抗肿瘤作用的潜在机制。
J Bone Oncol. 2020 Sep 15;25:100317. doi: 10.1016/j.jbo.2020.100317. eCollection 2020 Dec.
10
Prostate Cancer Theranostics - An Overview.前列腺癌诊疗一体化——概述
Front Oncol. 2020 Jun 5;10:884. doi: 10.3389/fonc.2020.00884. eCollection 2020.
本文引用的文献
1
Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype.前列腺癌转移细胞可指示造血干细胞和祖细胞调节骨表型。
Mol Cancer Res. 2012 Mar;10(3):282-92. doi: 10.1158/1541-7786.MCR-11-0404. Epub 2012 Jan 12.
2
Structure and function of the solid tumor niche.实体瘤微环境的结构与功能。
Front Biosci (Schol Ed). 2012 Jan 1;4(1):1-15. doi: 10.2741/s247.
3
The vascular niche: home for normal and malignant hematopoietic stem cells.血管壁龛：正常和恶性造血干细胞的家园。
Leukemia. 2012 Jan;26(1):54-62. doi: 10.1038/leu.2011.236. Epub 2011 Sep 2.
4
Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors.造血干细胞龛是治疗骨转移肿瘤的潜在靶点。
Clin Cancer Res. 2011 Sep 1;17(17):5553-8. doi: 10.1158/1078-0432.CCR-10-2505. Epub 2011 Jun 15.
5
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow.人前列腺癌转移定位于造血干细胞龛，在小鼠骨髓中建立立足点。
J Clin Invest. 2011 Apr;121(4):1298-312. doi: 10.1172/JCI43414. Epub 2011 Mar 23.
6
Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche.膜联蛋白-2 是基质细胞衍生因子-1/CXCL12 功能在造血干细胞骨内膜龛中的调节剂。
Exp Hematol. 2011 Feb;39(2):151-166.e1. doi: 10.1016/j.exphem.2010.11.007. Epub 2010 Nov 22.
7
Targeting the tumour vasculature: insights from physiological angiogenesis.靶向肿瘤血管：生理性血管生成的见解。
Nat Rev Cancer. 2010 Jul;10(7):505-14. doi: 10.1038/nrc2868.
8
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.骨内膜龛细胞群体的分离和鉴定及其对造血干细胞的调控作用。
Blood. 2010 Sep 2;116(9):1422-32. doi: 10.1182/blood-2009-08-239194. Epub 2010 May 14.
9
GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.GAS6/AXL 轴调控前列腺癌在骨髓微环境中的侵袭、增殖和存活。
Neoplasia. 2010 Feb;12(2):116-27. doi: 10.1593/neo.91384.
10
Expression of PGK1 by prostate cancer cells induces bone formation.前列腺癌细胞表达 PGK1 可诱导骨形成。
Mol Cancer Res. 2009 Oct;7(10):1595-604. doi: 10.1158/1541-7786.MCR-09-0072. Epub 2009 Oct 13.
Zotero 插件