Brunworth Joseph D, Mahboubi Hossein, Garg Rohit, Johnson Brandon, Brandon Bryan, Djalilian Hamid R
Ann Otol Rhinol Laryngol. 2014 Jun;123(6):415-9. doi: 10.1177/0003489414526689.
This study aimed to evaluate the relationship between nasopharyngeal pH and Eustachian tube dysfunction (ETD) in adults.
Unmatched case-control study.
Forty-one subjects, 20 adults with a diagnosis of ETD and 21 healthy adults as controls, were enrolled from an outpatient clinic. All subjects had a Dx-pH probe placed near the torus tubarius in the posterior nasopharynx for 24 hours. The pH values were recorded every 0.5 second. Decreases in pH were considered as reflux events if the pH dropped below 5.5.
The average nasopharyngeal pH value was 6.90 (range, 5.33-7.73) in the subjects with ETD and 7.07 (range, 5.99-7.94) in the controls. The difference between the 2 groups was not statistically significant (P = .30). The ETD group, on average, had a higher number of nasopharyngeal reflux events (2.3 +/- 1.6 vs 0.8 +/- 1.2, respectively; P = .002) and higher reflux finding score (3.6 +/- 2.7 vs 0.4 +/- 1.4, respectively; P < .00 I) than the control group.
By using a novel pH probe that allows detection of acidity in a nonliquid environment, a comparison of nasopharyngeal pH between control patients and those with ETD was performed. Eustachian tube dysfunction was more likely to be associated with a higher number of nasopharyngeal reflux events and higher reflux finding score. Nasopharyngeal reflux may have a role in the pathogenesis of ETD.
本研究旨在评估成人鼻咽pH值与咽鼓管功能障碍（ETD）之间的关系。
非匹配病例对照研究。
从门诊招募了41名受试者，其中20名被诊断为ETD的成人以及21名健康成人作为对照。所有受试者均在鼻咽后部的咽鼓管圆枕附近放置Dx-pH探头24小时。每0.5秒记录一次pH值。如果pH值降至5.5以下，则pH值下降被视为反流事件。
ETD受试者的平均鼻咽pH值为6.90（范围5.33 - 7.73），对照组为7.07（范围5.99 - 7.94）。两组之间的差异无统计学意义（P = 0.30）。平均而言，ETD组的鼻咽反流事件数量较多（分别为2.3±1.6和0.8±1.2；P = 0.002），反流发现评分也较高（分别为3.6±2.7和0.4±1.4；P < 0.001）。
通过使用一种新型pH探头，能够在非液体环境中检测酸度，对对照组患者和ETD患者的鼻咽pH值进行了比较。咽鼓管功能障碍更可能与较多的鼻咽反流事件和较高的反流发现评分相关。鼻咽反流可能在ETD的发病机制中起作用。
