酒精性心肌病：病理生理学见解
Alcoholic cardiomyopathy: pathophysiologic insights.
作者信息
Piano Mariann R, Phillips Shane A
机构信息
Department of Biobehavioral Health Science, University of Illinois at Chicago, 845 S. Damen Ave. (MC 807), Chicago, IL, 60612, USA,
出版信息
Cardiovasc Toxicol. 2014 Dec;14(4):291-308. doi: 10.1007/s12012-014-9252-4.
Abstract
Alcoholic cardiomyopathy (ACM) is a specific heart muscle disease found in individuals with a history of long-term heavy alcohol consumption. ACM is associated with a number of adverse histological, cellular, and structural changes within the myocardium. Several mechanisms are implicated in mediating the adverse effects of ethanol, including the generation of oxidative stress, apoptotic cell death, impaired mitochondrial bioenergetics/stress, derangements in fatty acid metabolism and transport, and accelerated protein catabolism. In this review, we discuss the evidence for such mechanisms and present the potential importance of drinking patterns, genetic susceptibility, nutritional factors, race, and sex. The purpose of this review is to provide a mechanistic paradigm for future research in the area of ACM.
摘要
酒精性心肌病（ACM）是一种在有长期大量饮酒史的个体中发现的特定心肌疾病。ACM与心肌内一些不良的组织学、细胞和结构变化有关。有多种机制参与介导乙醇的不良反应，包括氧化应激的产生、凋亡性细胞死亡、线粒体生物能量学/应激受损、脂肪酸代谢和转运紊乱以及蛋白质分解代谢加速。在本综述中，我们讨论了这些机制的证据，并阐述了饮酒模式、遗传易感性、营养因素、种族和性别的潜在重要性。本综述的目的是为ACM领域的未来研究提供一个机制范例。
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本文引用的文献
1
Biological markers of oxidative stress: Applications to cardiovascular research and practice.氧化应激的生物标志物：在心血管研究与实践中的应用
Redox Biol. 2013 Oct 8;1(1):483-91. doi: 10.1016/j.redox.2013.07.006.
2
Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats.慢性酒精摄入会破坏老年雌性 F344 大鼠而非成年雌性大鼠的心肌蛋白平衡和功能。
Am J Physiol Regul Integr Comp Physiol. 2014 Jan 1;306(1):R23-33. doi: 10.1152/ajpregu.00414.2013. Epub 2013 Nov 13.
3
Lipotoxicity in the liver.肝脏中的脂毒性。
World J Hepatol. 2013 Oct 27;5(10):550-7. doi: 10.4254/wjh.v5.i10.550.
4
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.线粒体功能障碍和自噬改变在心血管衰老和疾病中的作用：从机制到治疗。
Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H459-76. doi: 10.1152/ajpheart.00936.2012. Epub 2013 Jun 7.
5
2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.2013年美国心脏病学会基金会/美国心脏协会实践指南工作组关于心力衰竭管理的指南：美国心脏病学会基金会/美国心脏协会报告
J Am Coll Cardiol. 2013 Oct 15;62(16):e147-239. doi: 10.1016/j.jacc.2013.05.019. Epub 2013 Jun 5.
6
Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function.饮酒通过抑制内皮祖细胞的动员和功能，否定了雌激素介导的去卵巢小鼠的心肌修复。
J Biol Chem. 2013 Jun 21;288(25):18022-34. doi: 10.1074/jbc.M113.468009. Epub 2013 May 3.
7
Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and decreases ventricular contractile function in C57BL/6J mice.慢性乙醇摄入增加 C57BL/6J 小鼠心肌细胞脂肪酸摄取，降低心室收缩功能。
J Mol Cell Cardiol. 2013 Jun;59:30-40. doi: 10.1016/j.yjmcc.2013.02.005. Epub 2013 Feb 16.
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Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis.抑制细胞色素P450 2E1可减轻长期酒精摄入诱导的心肌收缩功能障碍和细胞凋亡。
Biochim Biophys Acta. 2013 Jan;1832(1):128-41. doi: 10.1016/j.bbadis.2012.08.014. Epub 2012 Sep 2.
9
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10
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