Department of Dermatology, Emory University, Atlanta, Georgia.
Department of Dermatology, Emory University, Atlanta, Georgia2Atlanta Veterans Administration Medical Center, Atlanta, Georgia.
JAMA Dermatol. 2014 Jun;150(6):613-20. doi: 10.1001/jamadermatol.2013.7696.
Chronic pruritus is a common problem with a deleterious effect on quality of life. The factors mediating the relationship between chronic pruritus and quality of life are poorly understood.
To determine the factors that mediate the impact of chronic pruritus on quality of life.
DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional study based on a nationwide telephone survey of US military veterans sampled from the Veterans Hospital Patient Database. Participants were veterans who agreed to participate and were found to have chronic pruritus.
Statistical significance of predictor variables (characteristics of patients and their chronic pruritus) in multivariate analysis using ItchyQoL scores as response variables.
Of 6000 veterans telephoned, 1075 consented to participate; 405 of these had chronic pruritus. Factors that mediated the impact of chronic pruritus on quality of life were demographic characteristics (age [P = .007], race [P = .05], marital status [P = .04]), personality (extroversion [P = .03], neuroticism [P = .01]), pruritus characteristics (severity [P < .001], duration [P = .01], frequency [P < .001], location [P = .005]), and possible etiology (cutaneous vs systemic [P = .03]). Notable factors not found significant include sex (P = .98) and socioeconomic variables (education level [P > .99], employment status [P = .53], income [P = .62]).
The multitude of factors that significantly influence the impact of chronic pruritus on quality of life demonstrates the complex nature of this relationship. A better appreciation of these factors will improve the clinical evaluation and treatment of chronic pruritus.
慢性瘙痒是一种常见的问题，对生活质量有不良影响。介导慢性瘙痒与生活质量之间关系的因素了解甚少。
确定介导慢性瘙痒对生活质量影响的因素。
设计、设置和参与者：基于全国性电话调查的横断面研究，在美国退伍军人医院患者数据库中抽取美国退伍军人作为样本。参与者为同意参与并被发现患有慢性瘙痒的退伍军人。
使用 ItchyQoL 评分作为反应变量，在多元分析中对预测变量（患者特征及其慢性瘙痒）的统计学意义进行分析。
在被电话联系的 6000 名退伍军人中，有 1075 人同意参与；其中 405 人患有慢性瘙痒。介导慢性瘙痒对生活质量影响的因素包括人口统计学特征（年龄 [P = .007]、种族 [P = .05]、婚姻状况 [P = .04]）、个性（外向性 [P = .03]、神经质 [P = .01]）、瘙痒特征（严重程度 [P < .001]、持续时间 [P = .01]、频率 [P < .001]、位置 [P = .005]）和可能的病因（皮肤与系统性 [P = .03]）。未发现显著相关的显著因素包括性别（P = .98）和社会经济变量（教育程度 [P > .99]、就业状况 [P = .53]、收入 [P = .62]）。
显著影响慢性瘙痒对生活质量影响的多种因素表明了这种关系的复杂性。更好地了解这些因素将改善慢性瘙痒的临床评估和治疗。
