Chesselet M F, Robbins E
Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129.
Neurosci Lett. 1989 Jan 2;96(1):47-53. doi: 10.1016/0304-3940(89)90241-3.
The distribution of neurons containing the messenger RNA encoding preprotachykinin, the precursor of the neuropeptides substance P and K, was examined in the striatum of the rat. The large majority of cells densely labelled by in situ hybridization histochemistry (using a 35S-radiolabelled RNA probe complementary of the beta-preprotachykinin mRNA) were located within the boundaries of areas of dense [3H]naloxone binding which delineate the striosomes, a striatal compartment distinct from the surrounding matrix with respect to its inputs, outputs and neurochemical content. In view of previous immunohistochemical data, the results suggest that tachykinin-containing neurons of the striosomes have a higher rate of tachykinin synthesis than those neurons located in the surrounding striatal matrix.
在大鼠纹状体中，对含有编码前速激肽原（神经肽P物质和K物质的前体）的信使核糖核酸的神经元分布进行了研究。通过原位杂交组织化学（使用与β-前速激肽原信使核糖核酸互补的35S放射性标记核糖核酸探针）进行密集标记的绝大多数细胞，位于界定纹状体小体区域的边界内，纹状体小体是纹状体的一个分区，在输入、输出和神经化学内容方面与周围基质不同。鉴于先前的免疫组织化学数据，结果表明，纹状体小体中含速激肽的神经元比位于周围纹状体基质中的神经元具有更高的速激肽合成速率。
