大鼠单侧残角子宫形成后卵巢储备功能的检测
Examination of the ovarian reserve after generation of unilateral rudimentary uterine horns in rats.
作者信息
Toyganözü Hasan, Nazik Hakan, Narin Raziye, Satar Deniz, Narin Mehmet Ali, Büyüknacar Sinem, Api Murat, Aytan Hakan
机构信息
Department of Obstetrics and Gynecology, Adana Numune Education and Research Hospital, 01330 Adana, Turkey.
Department of Pharmacology, Çukurova University Medical School, Adana, Turkey.
出版信息
ScientificWorldJournal. 2014 Feb 6;2014:918496. doi: 10.1155/2014/918496. eCollection 2014.
OBJECTIVE
The purpose of this experimental rat model study is to evaluate the changes in the ovarian environment after excision of the rudimentary horn.
METHODS
Ten female Wistar albino rats were used in this study. One cm of right uterine horn length was excised in the first operation. Two months after the first operation, all animals were sacrificed to obtain ovaries for histological examination. Mann-Whitney U test and Student's t-test were used for statistical analysis purposes. Statistical significance was defined as P < 0.005.
RESULTS
The number of primordial follicles (P = 0.415), primary follicles (P = 0.959), preantral follicles (P = 0.645), antral follicles (P = 0.328), and Graafian follicles (P = 0.721) was decreased and the number of atretic follicles (P = 0.374) increased in the right ovarian side. Howeve,r this difference was not found to be statistically significant.
CONCLUSION
The results of this experimental rat model study suggest that the excision of rudimentary horn could have negative effects on ipsilateral ovarian functions.
目的
本实验性大鼠模型研究的目的是评估残角切除术后卵巢环境的变化。
方法
本研究使用了10只雌性Wistar白化大鼠。在第一次手术中切除右侧子宫角1厘米的长度。第一次手术后两个月，处死所有动物以获取卵巢进行组织学检查。使用曼-惠特尼U检验和学生t检验进行统计分析。统计学显著性定义为P < 0.005。
结果
右侧卵巢侧的原始卵泡数量（P = 0.415）、初级卵泡数量（P = 0.959）、窦前卵泡数量（P = 0.645）、窦卵泡数量（P = 0.328）和格拉夫卵泡数量（P = 0.721）减少，闭锁卵泡数量（P = 0.374）增加。然而，未发现这种差异具有统计学显著性。
结论
本实验性大鼠模型研究的结果表明，残角切除可能对同侧卵巢功能产生负面影响。
Zotero 插件