Sawada Masato, Matsumoto Mami, Sawamoto Kazunobu
Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan.
Front Neurosci. 2014 Mar 17;8:53. doi: 10.3389/fnins.2014.00053. eCollection 2014.
Neural stem cells in the mammalian adult brain continuously produce new neurons throughout life. Accumulating evidence in rodents suggests that various aspects of adult neurogenesis, including the genesis, migration, and maturation of new neurons, are regulated by factors derived from blood vessels and their microenvironment. Brain injury enhances both neurogenesis and angiogenesis, thereby promoting the cooperative regeneration of neurons and blood vessels. In this paper, we briefly review the mechanisms for the vascular regulation of adult neurogenesis in the ventricular-subventricular zone under physiological and pathological conditions, and discuss their clinical potential for brain regeneration strategies.
哺乳动物成年大脑中的神经干细胞在整个生命过程中持续产生新的神经元。啮齿动物中越来越多的证据表明，成体神经发生的各个方面，包括新神经元的产生、迁移和成熟，都受到来自血管及其微环境的因子的调节。脑损伤会增强神经发生和血管生成，从而促进神经元和血管的协同再生。在本文中，我们简要回顾了生理和病理条件下室管膜下区成体神经发生的血管调节机制，并讨论了它们在脑再生策略中的临床潜力。
