Osamura R Y
Department of Pathology, Tokai University School of Medicine, Japan.
Pathol Res Pract. 1988 Sep;183(5):569-71. doi: 10.1016/s0344-0338(88)80012-8.
9 of 15 cases of GH secreting adenomas showed the localization of GH and a subunit in the adenoma cells. GH and a subunit were frequently colocalized in the same adenomas. Immunoelectron microscopically, GH and a subunit were localized in secretory granules which were packed in the cytoplasm. Immunoelectron microscopic double staining (preembedding method and post-embedding method) showed colocalization of GH and a subunit in the same secretory granules. These data suggested corelease of GH and a subunit by the same secretory granules.
15例生长激素分泌性腺瘤中有9例显示生长激素（GH）和α亚基在腺癌细胞中定位。GH和α亚基常共定位于同一腺瘤中。免疫电镜下，GH和α亚基定位于细胞质中充满的分泌颗粒内。免疫电镜双重染色（包埋前法和包埋后法）显示GH和α亚基在同一分泌颗粒中共定位。这些数据提示GH和α亚基由相同的分泌颗粒共同释放。
