Osamura R Y
Department of Pathology, Tokai University School of Medicine, Bohseidai, Kanagawa-ken, Japan.
Pathol Res Pract. 1988 Sep;183(5):606-9. doi: 10.1016/s0344-0338(88)80021-9.
Immunoelectron microscopic observations disclosed the presence of FSH alpha, beta subunits in secretory granules and rough endoplasmic reticulum (RER). Golgi saccules were consistently negative. The presence of these subunits in secretory granules which were located in the vicinity of RER or perinuclear spaces (PNS) suggested the possible formation of secretory granules in RER or PNS. The tumor cells showed heterogeneity in size and immunoreactivity of the secretory granules but non-neoplastic cells showed uniformity in these aspects.
免疫电子显微镜观察显示，促卵泡激素α、β亚基存在于分泌颗粒和粗面内质网（RER）中。高尔基体囊泡始终呈阴性。这些亚基存在于位于粗面内质网或核周间隙（PNS）附近的分泌颗粒中，提示可能在粗面内质网或核周间隙中形成分泌颗粒。肿瘤细胞在分泌颗粒的大小和免疫反应性方面表现出异质性，但非肿瘤细胞在这些方面表现出一致性。
