Knopfholz José, Disserol Caio César Diniz, Pierin Andressa Jardim, Schirr Fernanda Letícia, Streisky Larissa, Takito Lilian Lumi, Massucheto Ledesma Patrícia, Faria-Neto José Rocha, Olandoski Marcia, da Cunha Claudio Leinig Pereira, Bandeira Antonio Milton
Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, Prado Velho, 1155 Curitiba, PR, Brazil.
Cholesterol. 2014;2014:261878. doi: 10.1155/2014/261878. Epub 2014 Feb 6.
Currently, the Friedewald formula (FF) is the main method for evaluating low-density lipoprotein cholesterol (LDL-c). Recently, many limitations have emerged regarding its use, including patients with triglyceride levels ≥400 mg/dL, diabetes mellitus, and kidney or hepatic chronic diseases. We analyzed the use of the FF in patients with metabolic syndrome. We selected patients with known metabolic syndrome that fulfilled the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report and excluded patients with triglyceride levels ≥400 mg/dL and chronic liver and/or kidney disease. Using direct assays, we measured total cholesterol, high-density lipoprotein cholesterol, triglycerides, and LDL-c. Then, LDL-c was estimated using the FF and compared with the LDL-c by direct assay. The sample size was 135 patients. Using the FF, the mean LDL-c value was 124.4 ± 42.1 mg/dL; it was 125.1 ± 38.5 mg/dL by direct assay. The correlation coefficient between these two methods was 0.89, with statistical significance (P value < 0.001). There were no significant differences between the patients with triglyceride levels >150 mg/dL (P = 0.618). In conclusion, FF is a good method for estimating LDL-c in patients with metabolic syndrome.
目前，弗瑞德瓦尔德公式（FF）是评估低密度脂蛋白胆固醇（LDL-c）的主要方法。最近，其应用出现了许多局限性，包括甘油三酯水平≥400mg/dL的患者、糖尿病患者以及肾脏或肝脏慢性疾病患者。我们分析了FF在代谢综合征患者中的应用情况。我们选择了符合美国国家胆固醇教育计划成人高胆固醇检测、评估和治疗专家小组（成人治疗小组III）最终报告标准的已知代谢综合征患者，并排除了甘油三酯水平≥400mg/dL以及患有慢性肝脏和/或肾脏疾病的患者。通过直接检测法，我们测量了总胆固醇、高密度脂蛋白胆固醇、甘油三酯和LDL-c。然后，使用FF估算LDL-c，并与直接检测法测得的LDL-c进行比较。样本量为135名患者。使用FF时，平均LDL-c值为124.4±42.1mg/dL；直接检测法测得的值为125.1±38.5mg/dL。这两种方法之间的相关系数为0.89，具有统计学意义（P值<0.001）。甘油三酯水平>150mg/dL的患者之间无显著差异（P = 0.618）。总之，FF是估算代谢综合征患者LDL-c的一种好方法。
