低密度脂蛋白胆固醇：来自大型印度实验室数据库的弗瑞德沃德计算值与直接测量值的对比研究
LDL-cholesterol: Friedewald calculated versus direct measurement-study from a large Indian laboratory database.
作者信息
Kannan Subramanian, Mahadevan Shriraam, Ramji Bharath, Jayapaul Muthukumaran, Kumaravel V
机构信息
Consultant, Endocrinology Diabetes and Bariatric Medicine, Narayana Health City, Bangalore, Karnataka, India.
Endocrine and Speciality Clinic, Chennai, India.
出版信息
Indian J Endocrinol Metab. 2014 Jul;18(4):502-4. doi: 10.4103/2230-8210.137496.
BACKGROUND
Validity of Friedewald formula (FF) in patients with serum triglycerides (TGs) <400 mg/dl is unclear.
MATERIALS AND METHODS
We compared low-density lipoprotein (LDL)-cholesterol calculated by FF to directly measured LDL in a laboratory database of 14,620 lipid profile samples from south India.
RESULTS
LDL by FF correlated with directly measured LDL with correlation coefficient of 0.89 with the best correlation seen in TG levels 100-150. Higher level of TG (>200) underestimates the LDL calculated by FF particularly at LDL values <70 mg/dl. On the other hand, LDL is overestimated by FF in more than 70% of cases at LDL levels >130 mg/dl.
CONCLUSION
We suggest repeating the LDL by direct assay techniques particularly in patients with TG >200 and when LDL <70 or >130. This helps in correctly stratifying the coronary artery diseases' (CADs') risk and goals of treatment.
背景
对于血清甘油三酯（TGs）<400mg/dl的患者，Friedewald公式（FF）的有效性尚不清楚。
材料与方法
我们在一个来自印度南部的包含14620份血脂谱样本的实验室数据库中，将通过FF计算得出的低密度脂蛋白（LDL）胆固醇与直接测量的LDL进行了比较。
结果
通过FF得出的LDL与直接测量的LDL相关，相关系数为0.89，在TG水平为100 - 150时相关性最佳。较高的TG水平（>200）会低估通过FF计算得出的LDL，尤其是在LDL值<70mg/dl时。另一方面，在LDL水平>130mg/dl时，超过70%的病例中FF会高估LDL。
结论
我们建议通过直接检测技术重复测量LDL，特别是在TG>200以及LDL<70或>130的患者中。这有助于正确分层冠状动脉疾病（CADs）的风险和治疗目标。
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