Pugh Thomas J, Choi Seungtaek, Nguyen Quyhn Nhu, Gillin Michael T, Ron Zhu X, Palmer Matthew B, Lee Andrew K
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.
Pract Radiat Oncol. 2013 Apr-Jun;3(2):e87-94. doi: 10.1016/j.prro.2012.05.010. Epub 2012 Jul 12.
Proton beam therapy (PBT) offers the potential of dose escalation to target tissue while decreasing toxicity through unique physical dose deposition characteristics. PBT has been used to treat prostate cancer for several decades; however, recent enhancements in availability and treatment delivery have peaked interest in this technology among radiation oncologists, industry experts, and prostate cancer patients. As a result, the importance of understanding the collective experience and technical aspects of PBT delivery has become increasingly important in radiation medicine. This review article is intended to critically review the literature on PBT for localized prostate cancer, discuss the fundamentals of PBT treatment planning, and describe the continued development of proton beam technology for the treatment of prostate cancer.
质子束治疗（PBT）具有向靶组织增加剂量的潜力，同时通过独特的物理剂量沉积特性降低毒性。PBT已用于治疗前列腺癌数十年；然而，最近可用性和治疗实施方面的改进引发了放射肿瘤学家、行业专家和前列腺癌患者对该技术的浓厚兴趣。因此，了解PBT实施的总体经验和技术方面在放射医学中变得越来越重要。这篇综述文章旨在批判性地回顾关于局限性前列腺癌PBT的文献，讨论PBT治疗计划的基本原理，并描述用于治疗前列腺癌的质子束技术的持续发展。
