Svensson Rebecka, Ekström Curt
Department of Neuroscience, Ophthalmology, University Hospital, Uppsala, Sweden.
Acta Ophthalmol. 2015 Mar;93(2):162-4. doi: 10.1111/aos.12402. Epub 2014 Mar 26.
To study the relationship between pseudoexfoliation (PEX) and all-cause mortality in a population in which PEX is a common finding.
Survival analyses were performed in a cohort of 760 residents 65-74 years of age, examined in a population survey in the municipality of Tierp, Sweden, 1984-86. To expand the cohort, participants in other studies in Tierp were enrolled. Additionally, people were recruited by means of glaucoma case records established at the Eye Department in Tierp in 1978-2007. In this way, the cohort comprised 1524 subjects, representing more than 21,100 person-years at risk. Information on deaths was obtained from the local population register.
By the conclusion of the study, in August 2013, 1280 deaths had been reported. Of these cases, 350 were affected by PEX at baseline. No association between PEX and mortality was found (hazard ratio 1.00; 95% confidence interval 0.88-1.14).
The results strongly suggest that PEX had no effect on all-cause mortality in the population under study.
在假性剥脱（PEX）为常见现象的人群中研究PEX与全因死亡率之间的关系。
对760名65 - 74岁居民进行生存分析，这些居民于1984 - 1986年在瑞典蒂尔普市的一项人口调查中接受检查。为扩大队列，纳入了蒂尔普其他研究的参与者。此外，通过1978 - 2007年在蒂尔普眼科建立的青光眼病例记录招募人员。这样，该队列包括1524名受试者，代表超过21100人年的风险。死亡信息从当地人口登记处获得。
到2013年8月研究结束时，已报告1280例死亡。在这些病例中，350例在基线时受PEX影响。未发现PEX与死亡率之间存在关联（风险比1.00；95%置信区间0.88 - 1.14）。
结果强烈表明，PEX对所研究人群的全因死亡率没有影响。
