College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.
Department of Radiation Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Trends Microbiol. 2014 Jun;22(6):345-53. doi: 10.1016/j.tim.2014.02.009. Epub 2014 Mar 24.
Cervical cancer is the third most common cancer in women with human papillomavirus (HPV) being a key etiologic factor of this devastating disease. In this article, we describe modern advances in the genomics and transcriptomics of cervical cancer that led to uncovering the key gene drivers. We also introduce, herein, a model of cervical carcinogenesis that explains how the interplay between virus, tumor, and woman results in the selection of clones that simultaneously harbor genomic amplifications for genes that drive cell cycle, antiviral response, and inhibit cell differentiation. The new model may help researchers understand the controversies in antiviral therapy and immunogenetics of this cancer and may provide a basis for future research directions in early diagnostics and personalization of therapy.
宫颈癌是女性中第三常见的癌症，人乳头瘤病毒（HPV）是导致这种毁灭性疾病的关键病因。在本文中，我们描述了宫颈癌基因组学和转录组学的现代进展，这些进展揭示了关键的基因驱动因素。我们还在此介绍了一种宫颈癌发生模型，该模型解释了病毒、肿瘤和女性之间的相互作用如何导致同时具有驱动细胞周期、抗病毒反应和抑制细胞分化的基因的基因组扩增的克隆的选择。这个新模型可以帮助研究人员理解该癌症在抗病毒治疗和免疫遗传学方面的争议，并为早期诊断和治疗个体化的未来研究方向提供基础。
